Biocompatible and Biodegradable Magnesium Oxide Nanoparticles with In Vitro Photostable Near-Infrared Emission: Short-Term Fluorescent Markers
| Autor: | Ravi Shukla, Yanling He, Romina Norello, Alan Man Ching Ng, Timothy J. Karle, Bruce Mann, Asma Khalid, Richard De Boer, Andrea J. O'Connor, E. W. Lui, Snjezana Tomljenovic-Hanic, Aleksandra B. Djurišić, Phong A. Tran, Kenong Xia, Amanda N. Abraham, Jean-Philippe Tetienne |
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| Rok vydání: | 2019 |
| Předmět: |
Photoluminescence
Biocompatibility General Chemical Engineering fluorescence nanoparticles Nanoparticle Nanotechnology 02 engineering and technology magnesium oxide confocal microscopy 010402 general chemistry 01 natural sciences Article Nanomaterials lcsh:Chemistry Absorbance General Materials Science bioimaging biomarking Near-infrared spectroscopy technology industry and agriculture 021001 nanoscience & nanotechnology Fluorescence 0104 chemical sciences lcsh:QD1-999 cancer cells 0210 nano-technology Preclinical imaging |
| Zdroj: | Nanomaterials, Vol 9, Iss 10, p 1360 (2019) Nanomaterials Volume 9 Issue 10 |
| ISSN: | 2079-4991 |
| DOI: | 10.3390/nano9101360 |
| Popis: | Imaging of biological matter by using fluorescent nanoparticles (NPs) is becoming a widespread method for in vitro imaging. However, currently there is no fluorescent NP that satisfies all necessary criteria for short-term in vivo imaging: biocompatibility, biodegradability, photostability, suitable wavelengths of absorbance and fluorescence that differ from tissue auto-fluorescence, and near infrared (NIR) emission. In this paper, we report on the photoluminescent properties of magnesium oxide (MgO) NPs that meet all these criteria. The optical defects, attributed to vanadium and chromium ion substitutional defects, emitting in the NIR, are observed at room temperature in NPs of commercial and in-house ball-milled MgO nanoparticles, respectively. As such, the NPs have been successfully integrated into cultured cells and photostable bright in vitro emission from NPs was recorded and analyzed. We expect that numerous biotechnological and medical applications will emerge as this nanomaterial satisfies all criteria for short-term in vivo imaging. |
| Databáze: | OpenAIRE |
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