Hypoxia-inducible factor-1α expression in the gastric carcinogenesis sequence and its prognostic role in gastric and gastro-oesophageal adenocarcinomas
| Autor: | Helen R Valentine, P W Bishop, Catharine M L West, I. Welch, Susan Pritchard, Patricia M Price, Ewen A. Griffiths, N Whitchelo, Matthias P. A. Ebert |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty Esophageal Neoplasms Biopsy HIF-1α Adenocarcinoma Predictive Value of Tests Stomach Neoplasms medicine Humans Neoplasm Invasiveness Stomach cancer Molecular Diagnostics Survival rate Aged Aged 80 and over Staining and Labeling biology gastric cancer Intestinal metaplasia Middle Aged Helicobacter pylori Hypoxia-Inducible Factor 1 alpha Subunit Prognosis gastro-oesophageal junction tumours medicine.disease biology.organism_classification Immunohistochemistry digestive system diseases Survival Rate Oncology Dysplasia Multivariate Analysis Disease Progression Female Gastritis medicine.symptom Follow-Up Studies |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | Hypoxia-inducible factor-1 (HIF-1)alpha expression was studied in the gastric carcinogenesis sequence and as a prognostic factor in surgically resected gastric and gastro-oesophageal junction tumours. Protein expression was examined using immunohistochemistry on formalin-fixed biopsies of normal mucosa (n=20), Helicobacter pylori associated gastritis (n=24), intestinal metaplasia (n=24), dysplasia (n=12) and intestinal (n=19) and diffuse (n=21) adenocarcinoma. The relationship between HIF-1alpha expression and prognosis was assessed in resection specimens from 177 patients with gastric and gastro-oesophageal junction adenocarcinoma. Hypoxia-inducible factor-1alpha expression was not observed in normal gastric mucosa but increased in density (P |
| Databáze: | OpenAIRE |
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