Interactions between Pineal, Hypothalamus and Pituitary Involving Melatonin, MSH Release-Inhibiting Factor and MSH
| Autor: | Abba J. Kastin, Andrew V. Schally, M. Clinton Miller, Sharon Viosca, R.M.G. Nair |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Male
Hypothalamo-Hypophyseal System endocrine system medicine.medical_specialty Pituitary gland Dopamine MSH Release-Inhibiting Hormone medicine.medical_treatment Pinealectomy Melanocyte Biology Pineal Gland Melatonin Endocrinology Internal medicine medicine Animals Melanocyte-Stimulating Hormones Hypophysectomy Drug Synergism Amides Rats medicine.anatomical_structure Hypothalamus Glycine Melanocytes Chromatography Thin Layer Anura Leucine hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Endocrinology. 91:1323-1328 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo-91-5-1323 |
| Popis: | Increased melanocyte-lightening activity was found in the plasma of hypophysectomized rats as assayed by direct application to the pituitaries of frogs which had been previously darkened by removal of the hypothalamus. A decrease in this activity by destruction of the hypothalamus of the hypophysectomized rat suggested that MSH release-inhibiting factor (MIF) was involved. Pinealectomy of the hypophysectomized rat or extraction of the plasma with chloroform also decreased the plasma melanocyte-lightening activity, indicating the contribution of melatonin to the lightening effect. The presence of increased amounts of both Pro-Leu-Gly-NH2 (PLG), an MIF, and melatonin in the plasma of hypophysectomized rats, as compared with intact controls, was supported by the use of thin-layer chromatography. In addition, a potentiating action of PLG upon the skin lightening activity of melatonin was observed. These experiments suggest new dimensions to the pineal-hypothalamic-pituitary axis. (Endocrinology 91: 1323, 1972) |
| Databáze: | OpenAIRE |
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