NMDA receptors in the CeA and BNST differentially regulate fear conditioning to predictable and unpredictable threats
| Autor: | Travis D. Goode, Carolyn Evemy, Reed L. Ressler, Stephen Maren |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Cognitive Neuroscience Conditioning Classical Experimental and Cognitive Psychology Context (language use) Receptors N-Methyl-D-Aspartate Amygdala Article 050105 experimental psychology 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Avoidance Learning Animals Medicine Rats Long-Evans 0501 psychology and cognitive sciences Fear conditioning business.industry Central nucleus of the amygdala Central Amygdaloid Nucleus 05 social sciences Classical conditioning Fear Stria terminalis medicine.anatomical_structure nervous system NMDA receptor Conditioning Female Septal Nuclei business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neurobiol Learn Mem |
| ISSN: | 1074-7427 |
| DOI: | 10.1016/j.nlm.2020.107281 |
| Popis: | Considerable work demonstrates that Pavlovian fear conditioning depends on N-methyl-D-aspartate (NMDA) receptor-dependent plasticity within the amygdala. In addition, the bed nucleus of the stria terminalis (BNST) has also been implicated in fear conditioning, particularly in the expression of fear to poor predictors of threat. We recently found that the expression of backward (BW) fear conditioning, in which an auditory conditioned stimulus (CS) follows a footshock unconditioned stimulus (US), requires the BNST; the expression of forward (FW) fear conditioning was not disrupted by BNST inactivation. However, whether NMDA receptors within the BNST contribute to the acquisition of fear conditioning is unknown. Moreover, the central nucleus of the amygdala (CeA), which has extensive connections with the BNST, is critically involved in FW conditioning, however whether it participates in BW conditioning has not been explored. Here we test the specific hypothesis that the CeA and the BNST mediate the acquisition of FW and BW fear conditioning, respectively. Adult female and male rats were randomly assigned to receive bilateral infusions of the NMDA receptor antagonist, D,L-2-amino-5-phosphonovalerate (APV), into the CeA or BNST prior to FW or BW fear conditioning. We found that intra-CeA APV impaired the acquisition of both FW and BW conditioning, whereas intra-BNST APV produced selective deficits in BW conditioning. Moreover, APV in the BNST significantly reduced contextual freezing, whereas CeA NMDA receptor antagonism impeded early but not long-lasting contextual fear. Collectively, these data reveal that CeA and BNST NMDA receptors have unique roles in fear conditioning. |
| Databáze: | OpenAIRE |
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