Urinary leukotrienes and histamine in patients with varying severity of acute dengue
| Autor: | Graham S. Ogg, Chandima Jeewandara, Thilagaraj Pathmanathan, Sameera D. Mahapatuna, Chathurika Gangani, Laksiri Gomes, Ananda Wijewickrama, Tehani Silva, Gathsaurie Neelika Malavige |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
RNA viruses
Male 0301 basic medicine Viral Diseases Aging Physiology Social Sciences Urine Pathology and Laboratory Medicine Biochemistry Severity of Illness Index Gastroenterology Dengue Fever Dengue fever Dengue chemistry.chemical_compound Medical Conditions 0302 clinical medicine Animal Cells Medicine and Health Sciences Psychology Mast Cells Connective Tissue Cells Sex Characteristics Leukotriene Multidisciplinary Organic Compounds virus diseases Neurochemistry Neurotransmitters Viral Load Middle Aged respiratory system Body Fluids Chemistry Infectious Diseases Medical Microbiology Connective Tissue Viral Pathogens Creatinine Physical Sciences Viruses Acute Disease Biomarker (medicine) Medicine lipids (amino acids peptides and proteins) Female Pathogens Cellular Types Anatomy Viral load Histamine Research Article Neglected Tropical Diseases Adult Biogenic Amines Leukotrienes medicine.medical_specialty Urinary system Science 030231 tropical medicine Microbiology 03 medical and health sciences Virology Internal medicine medicine Humans Microbial Pathogens Behavior Flaviviruses business.industry Organic Chemistry Chemical Compounds Organisms Biology and Life Sciences Cell Biology Dengue Virus Tropical Diseases medicine.disease Kinetics Biological Tissue 030104 developmental biology chemistry Diurnal Variations business Viral Transmission and Infection Biomarkers Neuroscience |
| Zdroj: | PLoS ONE, Vol 16, Iss 2, p e0245926 (2021) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | BackgroundVascular leak is a hallmark of severe dengue, and high leukotriene levels have been observed in dengue mouse models, suggesting a role in disease pathogenesis. We sought to explore their role in acute dengue, by assessing levels of urinary LTE4 and urinary histamine in patients with varying severity of acute dengue.MethodsUrinary LTE4,histamine and creatinine were measured by a quantitative ELISA, in healthy individuals (n = 19), patients with dengue fever (DF = 72) and dengue haemorrhagic fever DHF (n = 48). The kinetics of LTE4 and histamine and diurnal variations were assessed in a subset of patients.ResultsUrinary LTE4 levels were significantly higher (p = 0.004) in patients who proceed to develop DHF when compared to patients with DF during early illness (≤ 4 days) and during the critical phase (p = 0.02), which continued to rise in patients who developed DHF during the course of illness. However, LTE4 is unlikely to be a good biomarker as ROCs gave an AUC value of 0.67 (95% CI 0.57 and 0.76), which was nevertheless significant (p = 0.002). Urinary LTE4 levels did not associate with the degree of viraemia, infecting virus serotype and was not different in those with primary vs secondary dengue. Urinary histamine levels were significantly high in patients with acute dengue although no difference was observed between patients with DF and DHF and again did not associate with the viraemia. Interestingly, LTE4, histamine and the viral loads showed a marked diurnal variation in both patients with DF and DHF.ConclusionsOur data suggest that LTE4 could play a role in disease pathogenesis and since there are safe and effective cysteinyl leukotriene receptor blockers, it would be important to assess their efficacy in reducing dengue disease severity. |
| Databáze: | OpenAIRE |
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