Lidocaine efficacy and toxicity assessed by a new, rapid method
| Autor: | Maria de Guzman, Kevin Buckman, Keith Claiborne, L. Julian Haywood, Clifford B. Walberg |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Central Nervous System
Male Chromatography Gas Time Factors Lidocaine Microgram Cardiovascular System Immunoenzyme Techniques Humans Medicine Pharmacology (medical) Pharmacology medicine.diagnostic_test business.industry Significant difference Age Factors Arrhythmias Cardiac Middle Aged Immunoenzyme techniques Anesthesia Immunoassay Toxicity Coronary care unit Female business medicine.drug |
| Zdroj: | Clinical Pharmacology and Therapeutics. 28:177-181 |
| ISSN: | 1532-6535 0009-9236 |
| DOI: | 10.1038/clpt.1980.147 |
| Popis: | Lidocaine (L) levels were measured by gas chromatography (GC) and a new technique of direct measurement by enzyme immunoassay (EMIT) in 50 consecutive patients admitted to the Coronary Care Unit who received L. There was no significant difference between the levels by the two techniques. There was eradication of most ventricular arrhythmias in 78% of patients, partial effectiveness in 16%, and no improvement in 6%. Toxicity was mainly mild central nervous system effects, noted in 26 of the 50 patients. All six patients with serum L above 5.9 microgram/ml had signs of toxicity. EMIT was found to be accurate and much faster than the traditional GC method. |
| Databáze: | OpenAIRE |
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