Trimethylamine-N-Oxide (TMAO) Predicts Cardiovascular Mortality in Peripheral Artery Disease
| Autor: | Sebastián Fernández-Alonso, Josune Orbe, José A. Páramo, Esther Martinez-Aguilar, Susana Ravassa, Alejandro Fernández-Montero, Jose A. Rodriguez, Ander Estella-Hermoso de Mendoza, Ana Ugarte, Julen Oyarzabal, Carmen Roncal, Goren Saenz-Pipaon, Leopoldo Fernández-Alonso |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Metabolite lcsh:Medicine Renal function Trimethylamine N-oxide Disease 030204 cardiovascular system & hematology Gastroenterology Risk Assessment Article Ciencias de la Salud::Cardiología [Materias Investigacion] 03 medical and health sciences chemistry.chemical_compound Methylamines Peripheral Arterial Disease Prognostic markers 0302 clinical medicine Internal medicine medicine Humans lcsh:Science Aged Multidisciplinary business.industry lcsh:R Confounding Critical limb ischemia Prognosis Intermittent claudication 030104 developmental biology chemistry Risk factors Outcomes research Cohort lcsh:Q Female medicine.symptom business |
| Zdroj: | Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019) Dadun. Depósito Académico Digital de la Universidad de Navarra instname |
| ISSN: | 2045-2322 |
| Popis: | Peripheral artery disease (PAD) is a major cause of acute and chronic illness, with extremely poor prognosis that remains underdiagnosed and undertreated. Trimethylamine-N-Oxide (TMAO), a gut derived metabolite, has been associated with atherosclerotic burden. We determined plasma levels of TMAO by mass spectrometry and evaluated their association with PAD severity and prognosis. 262 symptomatic PAD patients (mean age 70 years, 87% men) categorized in intermittent claudication (IC, n = 147) and critical limb ischemia (CLI, n = 115) were followed-up for a mean average of 4 years (min 1-max 102 months). TMAO levels were increased in CLI compared to IC (P 2.26 µmol/L exhibited higher risk of cardiovascular death (sub-hazard ratios ≥2, P |
| Databáze: | OpenAIRE |
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