Evidence of low-dose hyper-radiosensitivity in normal cells of cervix cancer patients?
| Autor: | B. Biesaga, K. Urbański, Z. Kojs, D. Słonina, Michael P. R. Waligórski |
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| Rok vydání: | 2006 |
| Předmět: |
Keratinocytes
Pathology medicine.medical_specialty Binucleated cells Uterine Cervical Neoplasms Radiation Dosage Models Biological Radiation Tolerance Reference Values medicine Humans Radiology Nuclear Medicine and imaging Computer Simulation Cervix Cells Cultured Micronuclei Chromosome-Defective Skin Radiation Evidence-Based Medicine Radiological and Ultrasound Technology business.industry Low dose Public Health Environmental and Occupational Health Cancer Dose-Response Relationship Radiation General Medicine Fibroblasts medicine.disease In vitro medicine.anatomical_structure Gamma Rays Micronucleus test Hyper radiosensitivity Female business Radiation response DNA Damage |
| Zdroj: | Radiation protection dosimetry. 122(1-4) |
| ISSN: | 0144-8420 |
| Popis: | The aim of the present study was to examine the low-dose radiation response of human normal cells using the micronucleus assay. Skin fibroblasts and keratinocytes derived from 40 cervix cancer patients were studied. After in vitro gamma irradiation with single doses ranging from 0.05 to 4 Gy, the fraction of binucleated cells with micronuclei was assessed. For each patient, the Linear-Quadratic (LQ) model and the Induced-Repair (IR) model were fitted over the whole data set (0.05-4 Gy). In conclusion, the present study showed some evidence of low-dose hypersensitivity in the fibroblasts of two patients and in the keratinocytes of four of the forty patients studied. |
| Databáze: | OpenAIRE |
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