Synthetic studies of carzinophilin. Part 2: Synthesis of 3,4-dibenzyloxy-2-methylidene-1-azabicyclo[3.1.0]hexane systems corresponding to the C1–C17 fragment of carzinophilin

Autor:	Miyoko Matsumoto, Shiro Terashima, Masaru Hashimoto
Rok vydání:	2003
Předmět:	Fragment (computer graphics) Stereochemistry Organic Chemistry General Medicine Carzinophilin Aziridine Ring (chemistry) Biochemistry Coupling reaction Hexane chemistry.chemical_compound chemistry Drug Discovery Derivative (chemistry)
Zdroj:	Tetrahedron. 59:3041-3062
ISSN:	0040-4020
DOI:	10.1016/s0040-4020(03)00378-8
Popis:	A model compound bearing the C1–C17 fragment of carzinophilin was synthesized. The synthesis involved coupling reaction of a cyclic thioimidate with the 4H-oxazol-5-one derivative, ring-opening of the 4H-oxazol-5-one to furnish a dehydropeptide system, elaboration of the C1–C6 enolamide, and construction of the aziridine ring as key steps.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81c4e33613e09ad9961aa4bac224c89a https://doi.org/10.1016/s0040-4020(03)00378-8 Zobrazit plný text záznamu Full Text from ScienceDirect