Abnormal expression of chemokine receptors on T-cells from patients with systemic lupus erythematosus
| Autor: | Kjell Eneslätt, Solbritt Rantapää-Dahlqvist, Karl-Gösta Sundqvist, Jyrki Ivanoff, Catharina Eriksson |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Receptors CCR6 Receptors CXCR5 CCR1 Receptors CXCR4 Pathology medicine.medical_specialty Chemokine Receptors CXCR3 T-Lymphocytes Receptors CCR1 Gene Expression C-C chemokine receptor type 6 030204 cardiovascular system & hematology Ligands CXCR3 Receptors Interleukin-8B CXCR5 03 medical and health sciences Chemokine receptor 0302 clinical medicine Rheumatology immune system diseases medicine Humans Lupus Erythematosus Systemic RNA Messenger Receptors Cytokine skin and connective tissue diseases Aged 030203 arthritis & rheumatology Lupus erythematosus biology business.industry Middle Aged medicine.disease Lupus Nephritis Rheumatoid arthritis Immunology biology.protein Cytokines Female Receptors Chemokine business |
| Zdroj: | Lupus. 12:766-774 |
| ISSN: | 1477-0962 0961-2033 |
| DOI: | 10.1191/0961203303lu467oa |
| Popis: | The expression of chemokine receptors on T-cells and chemokine levels in the blood was studied in 23 patients with SLE (ACR criteria), seven patients with rheumatoid arthritis (RA) and in 15 healthy controls using flow cytometry, RT-PCR and ELISA. The cell surface expression of the chemokine receptors CXCR5 and CCR6 was decreased in SLE patients compared with controls (P = 0.051 and P = 0.002, respectively). The decrease of CXCR5 was confined to SLE patients with inactive disease (SLEDAI6) compared with active disease (SLEDAI6) and controls. CXCR2 and CCR1 were increased in patients with active SLE compared with patients with inactive disease (P = 0.001 and P = 0.01, respectively) and with controls (P = 0.02 and P = 0.053, respectively). The levels of the chemokines MIP-1alpha MCP-1, SDF-1alpha, IP-10 and RANTES were significantly elevated in SLE patients compared with controls. Patients with renal involvement had increased surface expression of CXCR3 and CCR3 (P = 0.04 in both) and a lower level of soluble IP-10 compared with patients without renal disease (P = 0.025) and compared with controls (P = 0.001). The ratio between CCR5 and CCR3 was significantly increased in RA patients compared with SLE patients and controls supporting a Th1 overweight in RA. In conclusion, patients with SLE showed abnormal T-cell expression of several chemokine receptors and levels of soluble chemokines in their plasma/serum. |
| Databáze: | OpenAIRE |
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