The Effect of Intravenous Magnesium Sulphate as an Adjuvant in the Treatment of Acute Exacerbations of COPD in the Emergency Department: A Double-Blind Randomized Clinical Trial
| Autor: | Sepideh Amirifard, Hamed Amini Ahidashti, Fatemeh Jahanian, Iraj Goli Khatir |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Respiratory rate medicine.medical_treatment Chronic Obstructive Pulmonary Disease law.invention Magnesium Sulfate Pulmonary Disease Chronic Obstructive COPD exacerbation Randomized controlled trial Double-Blind Method law Internal medicine Intervention (counseling) Forced Expiratory Volume medicine Humans Magnesium Controlled Clinical Tria Saline COPD business.industry General Medicine Emergency department medicine.disease Sulfate Original Article business Emergency Service Hospital Intravenous magnesium Adjuvant |
| Zdroj: | Ethiopian Journal of Health Sciences |
| ISSN: | 2413-7170 |
| Popis: | BACKGROUND፡ Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are serious complications that often require immediate intervention in an emergency department (ED). The aim of this study was to investigate the effect of intravenous magnesium sulphate as an adjuvant in the treatment of AECOPD in the ED.METHODS: In a double-blind, randomized clinical trial, a total of 60 patients with AECOPD presenting to the ED of Imam Khomeini Hospital in Sari, Iran, were included. The study was conducted between September 2016 and February 2018. Eligible patients were randomly allocated into two groups of intervention and control. Patients in the intervention and control groups received intravenous infusion of magnesium sulfate (2 gr) or normal saline over 30 minutes, respectively. For all patients, Borgdyspnea score, forced expiratory volume in one second (FEV1) result and clinical variables of interest were evaluated before the beginning of the intervention, and also 45 minutes and 6 hours after the commencement of intervention.RESULTS: Regardless of time of evaluation, pulse rate (PR), respiratory rate (RR) and Borg score in intervention group was lower than control group. Also, FEV1 and SPO2 were greater in intervention group compared to control group. However, these differences were not statistically significant (between-subject differences or group effect) (p0.05).CONCLUSION: According to the results of this study, it seems that using intravenous magnesium sulfate has no significant effect on SPO2, FEV1, RR, and PR of patients with AECOPD who presented to ED. |
| Databáze: | OpenAIRE |
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