A prognostic role of mean 24-h pulse pressure level for cardiovascular events in type 2 diabetic subjects under 60 years of age
| Autor: | Makoto Nishizawa, Kazunori Konishi, Toshikazu Kigoshi, Atsushi Nakagawa, Kenzo Uchida, Keigo Uehara, Keisuke Furuya, Shigeru Nakano |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Adolescent Endocrinology Diabetes and Metabolism Blood Pressure Diabetic angiopathy Heart Rate Predictive Value of Tests Internal medicine Diabetes mellitus Internal Medicine medicine Humans Prospective Studies Prospective cohort study Pulse Aged Advanced and Specialized Nursing Aged 80 and over business.industry Patient Selection Blood Pressure Determination Blood Pressure Monitoring Ambulatory Middle Aged medicine.disease Prognosis Surgery Pulse pressure Blood pressure Quartile Diabetes Mellitus Type 2 Cardiovascular Diseases Predictive value of tests Ambulatory Cardiology Female business Diabetic Angiopathies Follow-Up Studies |
| Zdroj: | Diabetes care. 28(1) |
| ISSN: | 0149-5992 |
| Popis: | OBJECTIVE—To assess the prognostic role of ambulatory 24-h pulse pressure (PP) on various vascular events in relatively young type 2 diabetic subjects under 60 years of age. RESEARCH DESIGN AND METHODS—In this prospective study, 237 type 2 diabetic subjects without any history of vascular complications were analyzed. After excluding 9 dropout subjects, 228 subjects (mean age, 46 years; 69% men; mean follow-up period, 100 months) entered the study. RESULTS—Distribution of 24-h PP for all subjects showed left skewed data, indicating that there may be a diabetic subgroup that had a wide PP. Therefore, further analysis was performed by stratifying the diabetic subjects by quartile of 24-h PP. Outcomes for the widest quartile (n = 58; cut point = 53.3 mmHg) was then compared with those from the other narrower quartiles (n = 170). In the diabetic subjects with a wide PP, cardiovascular events occurred more frequently than those in the diabetic subjects with a narrow one (20.7 vs. 4.1%; P < 0.001), resulting in the significant difference in the cumulative incidence of cardiovascular events (P < 0.001, log-rank test), but not cerebrovascular events, between the two subgroups. The Cox model revealed that a wide 24-h PP at baseline independently predicted subsequent cardiovascular events but not cerebrovascular events. By contrast, only duration of diabetes was the risk factor for cerebrovascular events. CONCLUSIONS—This study showed that a wide 24-h PP is predictive for cardiovascular events in relatively young diabetic subjects. |
| Databáze: | OpenAIRE |
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