Active Targeting Towards and Inside the Brain based on Nanoparticles: A Review
| Autor: | Seyedeh Sabereh Samavati, Steven J. P. McInnes, Soheila Kashanian, Morteza Rabiei, Shahriar Jamasb |
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| Přispěvatelé: | Rabiei, Morteza, Kashanian, Soheila, Samavati, Seyedeh Sabereh, Jamasb, Shahriar, McInnes, Steven JP |
| Rok vydání: | 2020 |
| Předmět: |
Pharmaceutical Science
Capillary endothelial cells 02 engineering and technology Brain tissue Blood–brain barrier Capillary Permeability 03 medical and health sciences Drug Delivery Systems 0302 clinical medicine Glioma Animals Humans Nanotechnology Medicine hydrophobicity Brain Diseases Drug Carriers nanotechnology business.industry targeted delivery Brain Endothelial Cells blood-brain barrier 021001 nanoscience & nanotechnology medicine.disease Highly selective medicine.anatomical_structure Pharmaceutical Preparations Blood-Brain Barrier Drug delivery Nanoparticles nanoparticles 0210 nano-technology business Neuroscience neurological diseases 030217 neurology & neurosurgery Biotechnology |
| Zdroj: | Current Pharmaceutical Biotechnology. 21:374-383 |
| ISSN: | 1389-2010 |
| DOI: | 10.2174/1389201020666191203094057 |
| Popis: | In this study, a 1.1 MW diesel-gen-set is used to design a Waste Heat Recovery (WHR) system to generate additional power using Rankine cycle (RC). A computer code is written in commercial Engineering Equation Solver (EES) software to solve equations of overall energy and mass balance, heat transfer, evaporation, condensation, frictional and heat losses for heat exchangers, turbine, pumps, cooling tower and connecting pipes connecting different components. After initial design of the WHR system, manufacturers are contacted to find out the availability of parts, and then, accordingly the design is changed. There are several heat exchangers required to heat the water from liquid to super heated steam and then, it is passed to the turbine. Then, after the expansion in the turbine, it is passed to the condenser to condense the steam to water. Optimization is done on the heat exchangers, focusing on the tube length and diameter. The tube length is changed in accordance to the availability on the market, where it comes in 2 m length. At the rated power of the gen-set, with a pressure ratio of 100 (inlet and outlet pressures to the turbine are 30 bar and 0.3 bar, respectively), an overall improvement of 12.2% is achieved. Results from this study can be applied to large diesel engines used for large trucks which fall in the USA commercial truck category of Class 7 and 8 of heavy trucks, large diesel-gen-set and mobile applications such as ships, heavy construction equipment, ultra-heavy mining movers, excavators and locomotives. It found that the WHR system could be as heavy as the gen-set and they are bulky. Therefore, not only the overall efficiency improvement is important, the size and weight of the WHR system is also very important. Refereed/Peer-reviewed |
| Databáze: | OpenAIRE |
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