In-Vivo Gene Delivery by Sonoporation: Recent Progress and Prospects
| Autor: | Ayache Bouakaz, Anthony Novell, Aya Zeghimi, Jean-Michel Escoffre |
|---|---|
| Přispěvatelé: | Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM), Escoffre, Jean-Michel, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Tours (UT) |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Pathology
medicine.medical_specialty [SDV.BIO]Life Sciences [q-bio]/Biotechnology Genetic enhancement [SDV]Life Sciences [q-bio] 02 engineering and technology Gene delivery 01 natural sciences Genetic therapy Focused ultrasound 03 medical and health sciences 0302 clinical medicine In vivo 0103 physical sciences Drug Discovery Genetics Humans Medicine 010301 acoustics Molecular Biology Genetics (clinical) ComputingMilieux_MISCELLANEOUS 030304 developmental biology 0303 health sciences Microbubbles business.industry Gene Transfer Techniques Target tissue Genetic Therapy [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences 021001 nanoscience & nanotechnology [SDV.BIO] Life Sciences [q-bio]/Biotechnology [SDV] Life Sciences [q-bio] [SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciences Sound 030220 oncology & carcinogenesis Molecular Medicine Gases business 0210 nano-technology Sonoporation Neuroscience |
| Zdroj: | Current Gene Therapy Current Gene Therapy, Bentham Science Publishers, 2013, 13 (1), pp.2-14. ⟨10.2174/156652313804806606⟩ |
| ISSN: | 1566-5232 |
| DOI: | 10.2174/156652313804806606⟩ |
| Popis: | The increasing knowledge of cellular and molecular mechanisms of human diseases allows envisaging the gene therapy by sonoporation as an emerging and promising therapeutic alternative. Sonoporation combines the local application of ultrasound waves and the intravascular or intratissue administration of gas microbubbles. In such a way, the permeability of vessels and tissues to the poorly permeant molecules is transiently increased. Ultrasound based modality offers new opportunities since ultrasound can be easily focused on a target tissue or organ and hence gene delivery and expression should be limited to the insonified region. Consequently, it might be possible to develop an efficient and safe tissue- or organ-specific delivery method by microbubble targeting and focused ultrasound. This review focuses on the current knowledge of sonoporation fundamentals and mechanisms. The sonoporation procedure and current preclinical trials will be then presented. Finally, the new challenges of sonoporation will be discussed. |
| Databáze: | OpenAIRE |
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