Short-Term Toxicity of Mevinphos in Man
| Autor: | R. C. Hanisch, K. N. von Kaulla, H. G. Starr, John H. Holmes |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Adult
Atropine Male Insecticides Sarin medicine.medical_specialty Time Factors Vomiting medicine.medical_treatment Vision Disorders Physiology Poison control Excretion chemistry.chemical_compound Organophosphorus Compounds Fibrinolysis medicine Coagulation testing Cholinesterases Humans Environmental Chemistry Aged General Environmental Science Movement Disorders Pralidoxime Compounds business.industry Poisoning Public Health Environmental and Occupational Health Nausea Environmental Exposure Surgery Occupational Diseases Parathion chemistry Mevinphos Toxicity Blood Coagulation Tests business |
| Zdroj: | Archives of Environmental Health: An International Journal. 29:84-89 |
| ISSN: | 0003-9896 |
| DOI: | 10.1080/00039896.1974.10666538 |
| Popis: | This is a report of two cases of acute, moderate toxicity to mevinphos. Symptomatology was similar to that previously reported for exposure to parathion or sarin. Excretion pattern for the alkyl phosphate ester dimethylphosphate (DMP) shows rapid excretion that is almost complete 50 hours after exposure to mevinphos. Total excretion of DMP equivalent to 7.7 mg and 9.2 mg, respectively, of mevinphos was measured in two cases. Blood coagulation studies showed marked fibrinolysis in one case and marked hypercoagulability in the other, as demonstrated by the thrombin generation curve. Hematuria persisted in one patient for more than eight days. Both patients responded well to treatment. There was a five- to ten-hour delay between exposure and the patient reporting to the hospital for treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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