Hypereosinophilic syndrome – lymphocytic variant transforming into peripheral T-cell lymphoma with severe oral manifestations
| Autor: | Pierre Dubus, M. Longy Boursier, A. de Mascarel, Pierre Duffau, Patrick Mercié, Jean-Marie d’Elbée, Marie Parrens, Céline Dieval, Jean-Christophe Fricain |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Pathology medicine.medical_specialty Cyclophosphamide Hypereosinophilia CHOP Pathology and Forensic Medicine Fatal Outcome hemic and lymphatic diseases Hypereosinophilic Syndrome Humans Medicine Radiology Nuclear Medicine and imaging Dentistry (miscellaneous) Aged business.industry Hypereosinophilic syndrome Mouth Mucosa Antibodies Monoclonal Lymphoma T-Cell Peripheral medicine.disease Peripheral T-cell lymphoma Lymphoma Imatinib mesylate Surgery biological phenomena cell phenomena and immunity Oral Surgery medicine.symptom Tomography X-Ray Computed business Mepolizumab medicine.drug |
| Zdroj: | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 116:e185-e190 |
| ISSN: | 2212-4403 |
| DOI: | 10.1016/j.oooo.2013.03.017 |
| Popis: | Hypereosinophilic syndrome (HES) is a rare disease defined by organ damage directly attributable to hypereosinophilia of any type. Here, we report for the first time the case of a patient with a lymphocytic type of HES (HES-L) who had liver, skin, spleen, lung, bone marrow, digestive track, and mouth involvement. Associated T-cells displayed an aberrant CD30+ phenotype and were monoclonal. Thymus activated and regulated chemokine serum level was positive. Despite steroids (Cortancyl 20 mg [Sanofi Aventis, France], imatinib mesylate [Glivec 400 mg; Novartis Europharm], interferon alpha 2A [Roferon-A 3 MUI/0.5 ml; Roche]) and other lines of therapy including imatinib mesylate treatment, an oral necrotic lesion developed, and finally progressed into a peripheral CD30+ T-cell lymphoma. CHOP chemotherapy (cyclophosphamide, hydroxydoxorubicin, oncovin, prednisone), interferon-α, and mepolizumab were ineffective. Although progression into peripheral T-cell lymphoma is documented as a rare complication of HES-L, severe oral extension of HES-L is described for the first time. |
| Databáze: | OpenAIRE |
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