Does supportive pamidronate treatment prevent or delay the first manifestation of bone metastases in breast cancer patients?
| Autor: | Jo Hermans, G. Blijham, Louk V.A.M. Beex, A.T.M. van Holten-Verzantvoort, Socrates E. Papapoulos, F.J. Cleton, B.C.F. van Eck-Smit, Harm Sleeboom |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty Pamidronate Bone Neoplasms Breast Neoplasms Breast cancer Risk Factors medicine Humans GeneralLiterature_REFERENCE(e.g. dictionaries encyclopedias glossaries) Aged Aged 80 and over Diphosphonates business.industry Clinical events Middle Aged medicine.disease Surgery Survival Rate Oncology Tumour therapy Locally advanced disease Quality of Life Female business |
| Zdroj: | European Journal of Cancer, 32, 450-454 European Journal of Cancer, 32, 3, pp. 450-454 |
| ISSN: | 0959-8049 |
| Popis: | The effect of pamidronate treatment on the first development of bone metastases was investigated in 124 patients with breast cancer, with either locally advanced disease (n = 33) or extraskeletal metastases (n = 91), but no bone metastases in a randomised, multicentre, open controlled study. Patients were assigned to treatment with oral pamidronate, 300 mg/day, (n = 65) or to a control group (n = 59). Tumour therapy was freely allowed. A first clinical event of skeletal morbidity occurred in 22% pamidronate and 20% control patients; unequivocal first radiological manifestation of bone metastases was found in 36% pamidronate and 27% control patients (n.s.). The actuarial risk of a first skeletal event was similar in both groups. Quality-of-life measurements of bone metastases-related aspects showed no differences between the two groups. 19 patients withdrew from the study because of gastrointestinal complaints attributed to pamidronate. We conclude that supportive oral pamidronate treatment (300 mg/day) does not prevent nor delay the development of bone metastases in breast cancer patients at risk. |
| Databáze: | OpenAIRE |
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