Uveal melanoma-associated survival in Scotland
Autor: | Lesley A Bhatti, Paul Cauchi, Ewan G Kemp, Vikas Chadha, Aaron Jamison, Manvi M Sobti |
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Rok vydání: | 2019 |
Předmět: |
Adult
Male Uveal Neoplasms medicine.medical_specialty Adolescent education Age at diagnosis Medical Oncology Credentialing Article 03 medical and health sciences 0302 clinical medicine Continuing medical education Cause of Death Internal medicine medicine Humans Iris Neoplasms Melanoma Aged Retrospective Studies Aged 80 and over business.industry Choroid Neoplasms Ciliary Body Pharmacy education Middle Aged medicine.disease Ocular oncology Survival Rate Ophthalmology Scotland Release date 030221 ophthalmology & optometry Female business 030217 neurology & neurosurgery Cohort study |
Zdroj: | Eye (Lond) |
ISSN: | 1476-5454 0950-222X |
Popis: | Upon completion of this activity, participants will be able to: In support of improving patient care, this activity has been planned and implemented by Medscape, LLC and Springer Nature. Medscape, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team. Medscape, LLC designates this Journal-based CME activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. 1.0 Release date: 25 October 2019 Expiration date: 25 October 2020 Post-test link: https://medscape.org/eye/posttest918527 S.S. has disclosed the following relevant financial relationships: Served as an advisor or consultant for: Allergan, Inc.; Bayer AG; Boehringer Ingelheim Pharmaceuticals, Inc.; Heidelberg Pharma GmbH; Optos; Roche. Served as a speaker or a member of a speakers bureau for: Allergan, Inc.; Bayer AG; Novartis Pharmaceuticals Corporation; Optos. Received grants for clinical research from: Allergan, Inc.; Bayer AG; Boehringer Ingelheim Pharmaceuticals, Inc.; Novartis Pharmaceuticals Corporation; Optos. A.J., L.B., M.S., V.C., P.C., and E.K. have disclosed no relevant financial relationships. Laurie Barclay has disclosed no relevant financial relationships. The Scottish Ocular Oncology Service (SOOS) manages all patients with uveal melanoma (UM) in Scotland. Our aim was to determine the long-term all-cause and cause-specific survival of patients with UM, irrespective of treatment modality. A retrospective single-centre cohort study including all patients diagnosed with UM by the SOOS between 1/1/1998 and 31/12/2002. Data from the SOOS database were correlated with death records held by National Records of Scotland, which provided date, and all listed causes, of death for all deceased patients. Two hundred and eighteen patients were newly diagnosed with UM between 1/1/1998 and 31/12/2002. One hundred and fifteen (52.8%) were female. The mean (median) age at diagnosis was 63(65) years (range: 16–89). Of 179 choroidal melanomas, melanoma-specific survival was 92.3%, 87.4% and 83.8% at 5, 10 and 15 years, respectively. Cancer-specific survival was 85.8%, 71.8% and 62.3%. All-cause survival was 81.6% (146/179), 62.0% (111/179) and 46.7% (computed, fraction inexpressible). Of 26 ciliary body melanomas, melanoma-specific survival was 87.2%, 81.3% and 81.3% at 5, 10 and 15 years. Cancer-specific survival was 62.9%, 40.6% and 40.6%. All-cause survival was 61.5% (16/26), 38.5% (10/26) and 26.9% (7/26). Of 13 iris melanomas, at all three timepoints (5/10/15 years), melanoma-specific survival was 100%, cancer-specific survival was 92.3%, and all-cause survival was 76.9% (10/13). Correlation of SOOS and national records survival data confirms 15-year melanoma-specific survival of 83.8%, 81.3% and 100% for choroidal, ciliary body and iris melanomas, respectively. We can now provide accurate survival data to our patients in Scotland. |
Databáze: | OpenAIRE |
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