Computer-Aided Detection and Evaluation of Lipid-Rich Plaque on Noncontrast Cardiac CT
| Autor: | Sean W. Hayes, Heidi Gransar, John D. Friedman, Nathan D. Wong, Hidetaka Nishina, Daniel S. Berman, Romalisa Miranda-Peats, Fatma Aboul-Enein, Damini Dey, Piotr J. Slomka, Tracy Q. Callister, Xingping Kang |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Gauche effect chemistry.chemical_element Coronary Disease Calcium computer.software_genre Electron beam tomography Voxel Hounsfield scale medicine Humans Radiology Nuclear Medicine and imaging Diagnosis Computer-Assisted Cardiac imaging Aged Retrospective Studies Framingham Risk Score medicine.diagnostic_test business.industry General Medicine Middle Aged Lipids chemistry Female Tomography Radiology Tomography X-Ray Computed business Nuclear medicine computer Software |
| Zdroj: | American Journal of Roentgenology. 186:S407-S413 |
| ISSN: | 1546-3141 0361-803X |
| DOI: | 10.2214/ajr.05.0189 |
| Popis: | Noncontrast electron beam CT (EBCT) and MDCT are established for the assessment of calcified plaque, but not lipid-rich plaque. We developed software to identify lipid-rich plaque with noncontrast electron beam tomography (EBT) and MDCT.A computer algorithm was developed to automatically find contiguous lipid-rich lesions with voxel intensities below a calculated patient-specific lipid threshold. Lipid density and lipid inhomogeneity in Hounsfield units were calculated in the proximal left coronaries of three populations: 34 low-risk patients (low-risk group6% Framingham risk score, no calcium), 31 high-risk patients (high-risk group20% Framingham risk score, no calcium), and 37 patients with calcified plaque (calcium group).The mean lipid density was -19.6 +/- 3.0 (SD) H in the low-risk group, -25.3 +/- 8.2 H in the high-risk group, and -34.3 +/- 13.0 H in the calcium group (p0.05). The mean lipid inhomogeneity was 17.7 +/- 3.6 H in the low-risk group, 21.5 +/- 5.5 H in the high-risk group, and 29.0 +/- 7.6 H in the calcium group (p0.05). The mean interscan variability in lipid density and lipid inhomogeneity were 2.0 +/- 3.3 H and 2.1 +/- 3.6 H, respectively. In five patients, the locations of lipid-rich plaque correlated well with available intravascular sonography findings.Our method may be able to identify lipid-rich plaque on noncontrast cardiac CT. |
| Databáze: | OpenAIRE |
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