Clinical and nasal biopsy response to treatment of perennial rhinitis
| Autor: | Gerald M. English, Lowell Jones, Sheldon L. Spector |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Adult
Male medicine.medical_specialty Nasal biopsy Rhinitis Allergic Perennial Adolescent Immunology Inflammation Placebo Gastroenterology Leukocyte Count Internal medicine Edema Biopsy medicine Flunisolide Humans Immunology and Allergy Aged Physician-Patient Relations medicine.diagnostic_test business.industry Perennial rhinitis Middle Aged Response to treatment Respiratory Function Tests Surgery Eosinophils Nasal Mucosa Fluocinolone Acetonide Female medicine.symptom business medicine.drug |
| Zdroj: | Journal of Allergy and Clinical Immunology. 66:129-137 |
| ISSN: | 0091-6749 |
| Popis: | Nasal biopsies of patients with perennial rhinitis were performed at baseline and compared with biopsies performed 4 wk after active flunisolide, 50 μg four times per day, or placebo. An effort was made to relate histologic findings to other subjective and objective parameters as an indication of response to treatment. Although patients admitted to the study had severe subjective nasal symptoms, biopsies varied considerably. Some resembled biopsies from normal individuals, and others showed marked edema and inflammation; the latter findings were more typically present in the biopsies of patients with the most severe disease. A decrease in edema and loss of inflammatory cells on biopsy as well as a corresponding decrease in eosinophils on the nasal smear usually accompanied clinical improvement, which occurred in both the active and placebo groups. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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