Experimental Spinal Cord Injury
| Autor: | David B. Hackney, John C. Ford, Christopher M. Hand, Ronald S. Markowitz, Perry Black, Peter M. Joseph |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.diagnostic_test
business.industry Spinal Cord Trauma Magnetic resonance imaging Anatomy medicine.disease Weight drop Magnetic Resonance Imaging Rats Intensity (physics) Rats Sprague-Dawley Lesion Central nervous system disease Correlation Spinal Cord medicine Animals Radiology Nuclear Medicine and imaging medicine.symptom business Spinal cord injury Spinal Cord Injuries |
| Zdroj: | Journal of Computer Assisted Tomography. 18:357-362 |
| ISSN: | 0363-8715 |
| DOI: | 10.1097/00004728-199405000-00004 |
| Popis: | OBJECTIVE This study was conducted to determine the association between lesion length measured on MRI and the severity of mechanical injury in a rat model of spinal cord trauma. MATERIALS AND METHODS Sprague-Dawley rats were subjected to a modified Allen weight drop injury and killed 4 h after injury. Their fixed, exercised cords were studied with MRI at 1.9 T. RESULTS There were strong correlations between lesion length on MR images and weight drop height and square root of drop height (r2 = 0.55, p < 0.0001 and r2 = 0.63, p < 0.0001, respectively). The lesion length differences were significant versus controls for all drop heights at p values of < or = 0.002 and for the 2.5 cm animals versus the 5 and 15 cm animals (p = 0.01 and p = 0.0002, respectively), but the lengths of the 5 vs. 15 cm groups only approached significance (p = 0.06). CONCLUSION These results suggest that lesion length determined on MR images is a reliable indicator of the severity of trauma among animals subjected to weight drop injury. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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