The encapsulation of a model protein in poly (D, L lactide-co-glycolide) microparticles of various sizes: an evaluation of process reproducibility
| Autor: | H Qiu, Derek T. O'Hagan, Xuan-Mao Li, Manmohan Singh, J.P. McGee |
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| Rok vydání: | 1997 |
| Předmět: |
Reproducibility
Materials science Chromatography Ovalbumin Polymers Organic Chemistry Reproducibility of Results Pharmaceutical Science Model protein Bioengineering Controlled release Dosage form Colloid and Surface Chemistry Polylactic Acid-Polyglycolic Acid Copolymer Solvent evaporation Scientific method Polymer chemistry Lactic Acid Particle size Particle Size Physical and Theoretical Chemistry Microparticle Polyglycolic Acid |
| Zdroj: | Journal of Microencapsulation. 14:197-210 |
| ISSN: | 1464-5246 0265-2048 |
| DOI: | 10.3109/02652049709015333 |
| Popis: | Poly (D, L lactide-co-glycolide) and poly (D, L lactide) microparticles were prepared by solvent evaporation and the process reproducibility was evaluated in terms of the loading of a model protein into the microparticles, the microparticle size and the in-vitro release profiles of the protein. The results showed that the microencapsulation method allowed the preparation of microparticles with mean sizes from0.5 micron to 100 microns in size, with protein entrapment from 0.5 to 5% w/w. The microparticles were smooth and free from surface defects. Moreover, the reproducibility of the preparation method was demonstrated by the in-vitro release profiles obtained using different batches of microparticles prepared under similar conditions and by the reproducibility of microparticle size and protein loading. The results demonstrated that the preparation method was both robust and reproducible and allowed the preparation of microparticles with desired characteristics in terms of loading levels, particle size and release rates. |
| Databáze: | OpenAIRE |
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