Interaction between Nm23 and the tumor suppressor VHL
| Autor: | Boris Adryan, Tien Hsu, Vincent Dammai, Chih-Hung Lin |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
DNA
Complementary Tumor suppressor gene Endocytic cycle Biology law.invention chemistry.chemical_compound law Cell Line Tumor Two-Hybrid System Techniques Animals Drosophila Proteins Humans Receptor Fibroblast Growth Factor Type 1 Receptor Gene Pharmacology Genetics HEK 293 cells General Medicine NM23 Nucleoside Diphosphate Kinases Cell biology HEK293 Cells chemistry Von Hippel-Lindau Tumor Suppressor Protein Nucleoside-Diphosphate Kinase Suppressor Drosophila Function (biology) DNA |
| Zdroj: | Naunyn-Schmiedeberg's Archives of Pharmacology. 388:143-152 |
| ISSN: | 1432-1912 0028-1298 |
| DOI: | 10.1007/s00210-014-1002-4 |
| Popis: | Among the anti-tumor genes (tumor suppressors and metastasis suppressors), the von-Hippel Lindau gene and the Nm23 family of genes are among the more intriguing ones. Both are small (long and short forms of VHL are 30 and 19 kD, respectively, and Nm23 is ~17 kD), and both possess diverse molecular and cellular functions. Despite extensive studies, the entire spectra of functions and the molecular function-phenotype correlation of these two proteins have not been completely elucidated. In this report, we present data showing these two proteins interact physically. We also summarize and confirm the previous studies that demonstrated the endocytic function of these two genes and further show that the endocytic function of VHL is mediated through the activity of Nm23. These functional and molecular interactions are evolutionarily conserved from Drosophila to human. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink