When Clinical Trial Participation Is Not an Option in the Era of Personalized Medicine: The Case of Two Patients

Autor:	Steve Ades, Hibba tul Rehman, Edmund Folefac, Julian Sprague, Bhargavi Pulluri, Kim Dittus, Chris E. Holmes, Pamela C. Gibson, Claire F. Verschraegen, James DeKay, Maura Barry
Rok vydání:	2016
Předmět:	Male Cancer Research medicine.medical_specialty Skin Neoplasms medicine.medical_treatment Alternative medicine MEDLINE Thyroid Carcinoma Anaplastic Targeted therapy 03 medical and health sciences 0302 clinical medicine Humans Medicine In patient 030212 general & internal medicine Precision Medicine Intensive care medicine Melanoma Aged Clinical Trials as Topic business.industry Liver Neoplasms Complete remission General Medicine Middle Aged Anticancer drug Clinical trial Oncology 030220 oncology & carcinogenesis Female Personalized medicine business
Zdroj:	Oncology. 92:55-60
ISSN:	1423-0232 0030-2414
DOI:	10.1159/000450712
Popis:	The combination of personalized therapy with immunotherapy might lead to rapid complete remission in patients who are too sick to be eligible for clinical trials. We report 2 such extraordinary responders. A discussion on the use and purpose of clinical trials in this new era of very active anticancer drug discovery concludes that a paradigm shift is urgently needed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b1f393f00b9c4f6b34447f331876c0 https://doi.org/10.1159/000450712 Zobrazit plný text záznamu