Peripheral blood stem cell mobilization by granulocyte colony-stimulating factor alone and engraftment kinetics following autologous transplantation in children and adolescents with solid tumor
| Autor: | Michiya Kaneko, Takanori Abe, Shoji Kagami, Toshihiro Onishi, Hiroko Suzuya, Tsutomu Watanabe, Yoshifumi Wakata, Yasuhiro Okamoto, Yoichi Takaue, Hiroyoshi Watanabe, Yoshifumi Kawano |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Transplantation Conditioning Adolescent medicine.medical_treatment CD34 Antigens CD34 Granulocyte Transplantation Autologous Gastroenterology Neoplasms Internal medicine Antineoplastic Combined Chemotherapy Protocols Granulocyte Colony-Stimulating Factor medicine Humans Transplantation Homologous Autologous transplantation Progenitor cell Child Retrospective Studies Peripheral Blood Stem Cell Transplantation Transplantation Chemotherapy Hematology business.industry Graft Survival Infant Hematopoietic Stem Cell Mobilization Granulocyte colony-stimulating factor Surgery Kinetics Treatment Outcome medicine.anatomical_structure Child Preschool Female Stem cell business |
| Zdroj: | Bone Marrow Transplantation. 37:661-668 |
| ISSN: | 1476-5365 0268-3369 |
| DOI: | 10.1038/sj.bmt.1705304 |
| Popis: | In 56 pediatric and adolescent patients (median age 7 years, range 1-21) with various solid tumors, peripheral blood stem cells (PBSC) were mobilized with granulocyte colony-stimulating factor (G-CSF) alone, and the yields of PBSC and engraftment kinetics following autologous peripheral blood stem cell transplantation (PBSCT) were evaluated retrospectively. Granulocyte colony-stimulating factor (10 microg/kg) was injected subcutaneously for mobilization when patients showed no influence of previous chemotherapy, and administration was continued for 5 days. The peaks of CD34+ cells and colony-forming units-granulocyte/macrophage in the blood were observed on days 4 through 6 of G-CSF administration in all patients. Peripheral blood stem cell harvest was commenced on day 5 of G-CSF treatment. Compared to the results in patients mobilized by chemotherapy plus G-CSF (N=18), the progenitor cell yields were lower in patients mobilized with G-CSF alone. However, there were no significant differences in WBC and ANC engraftment compared to the chemotherapy plus G-CSF mobilization group. Platelet recovery following autologous PBSCT was delayed in patients mobilized with G-CSF alone. The median time taken for ANC and platelet counts to reach 0.5 x 10(9) and 20 x 10(9)/l was 12 days (range: 9-28) and 15 days (8-55), respectively, in all patients who received PBSC mobilized by G-CSF alone. In summary, mobilization with G-CSF alone can mobilize sufficient CD34+ cells for successful autografting and sustained hematological reconstitution in pediatric and adolescent patients with solid tumors, and even in heavily pre-treated patients. |
| Databáze: | OpenAIRE |
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