Formula-syndrome correlation study of three classical anti-jaundice formulas in inhibition of liver fibrosis induced by dimethylnitrosamine in rats
| Autor: | Jia Liu, Gao-feng Chen, Hongyan Cao, Yanqin Bian, Ning Bingbing, Cheng Liu, Mingyu Sun, Lu Yan, Ping Liu |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Intraperitoneal injection Decoction Liver Cirrhosis Experimental Dimethylnitrosamine law.invention Pathogenesis Hydroxyproline chemistry.chemical_compound law Internal medicine medicine Animals Rats Wistar business.industry Histology Jaundice Rats Endocrinology Liver Complementary and alternative medicine chemistry Liver function medicine.symptom Phytotherapy business Drugs Chinese Herbal |
| Zdroj: | Journal of Chinese Integrative Medicine. :1405-1412 |
| ISSN: | 1672-1977 |
| DOI: | 10.3736/jcim20121212 |
| Popis: | OBJECTIVE To investigate the effects of three classical anti-jaundice formulas Yinchenhao Decoction (YCHD). Yinchen Wuling San (YCWLS) and Zhizi Baipi Decoction (ZZBPD) on liver fibrosis induced by dimethylnitrosamine (DMN) in rats and explore the formula-syndrome relationship. METHODS Forty-eight rats were weighted, and divided into five groups: normal control, DMN, YCHD, YCWLS and ZZBPD groups using stratified random method. Liver fibrosis in rats was induced by intraperitoneal injection of DMN for 4 weeks at the dosage 10 mg/kg body weight, once per day for 3 consecutive days in each week. Each groups was gavaged with distilled water (control or model group), YCHD, YCWLS and ZZBPD respectively in the last 2-week modeling period. At the end of the 4th week, rats were sacrificed and their blood sample and liver tissue were taken for detecting pathology and analyzing of hydroxyproline (Hyp) and liver function. RESULTS Compared with the normal control group, DMN model group showed liver damage and liver fibrosis with remarkably increased Hyp content (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|