3D printing of HA / PCL composite tissue engineering scaffolds
| Autor: | Weimin Yang, Xiang Shengyi, Bin Luo, Zhiwei Jiao, Yuan Yu, Ma Haopeng |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Scaffold
Materials science Polymers and Plastics Materials Science (miscellaneous) Composite number 3D printing macromolecular substances Industrial and Manufacturing Engineering law.invention chemistry.chemical_compound Flexural strength Tissue engineering law Ultimate tensile strength Chemical Engineering (miscellaneous) Composite material Fused deposition modeling business.industry technology industry and agriculture equipment and supplies musculoskeletal system lcsh:TP1080-1185 lcsh:Polymers and polymer manufacture chemistry lcsh:TA1-2040 Polycaprolactone lcsh:Engineering (General). Civil engineering (General) business |
| Zdroj: | Advanced Industrial and Engineering Polymer Research, Vol 2, Iss 4, Pp 196-202 (2019) |
| ISSN: | 2542-5048 |
| DOI: | 10.1016/j.aiepr.2019.09.003 |
| Popis: | Here, the internal structure and mechanical properties of the hydroxyapatite/polycaprolactone scaffolds, prepared by fused deposition modeling (FDM) technique, were explored. Using hydroxyapatite (HA) and polycaprolactone (PCL) as raw materials, nano-HA/PCL and micro-HA/PCL that composite with 20 wt% HA were prepared by melt blending technology, and HA/PCL composite tissue engineering scaffolds were prepared by self-developed melt differential FDM 3D printer. From the observation under microscope, it was found that the prepared nano-HA/PCL and micro-HA/PCL tissue engineering scaffolds have uniformly distributed and interconnected nearly rectangular pores. By observing the cross-sectional view of the nano-HA/PCL scaffold and the micro-HA/PCL scaffold, it is known that the HA particles in the nano-HA/PCL scaffold are evenly distributed and the HA particles in the micro-HA/PCL scaffold are agglomerated, which attribute nano-HA/PCL scaffolds with higher tensile strength and flexural strength than the micro-HA/PCL scaffolds. The tensile strength and flexural strength of the nano-HA/PCL specimens were 23.29 MPa and 21.39 MPa, respectively, which were 26.0% and 33.1% higher than those of the pure PCL specimens. Therefore, the bioactive nano-HA/PCL composite scaffolds prepared by melt differential FDM 3D printers should have broader application prospects in bone tissue engineering. Keywords: Fused deposition modeling FDM, Hydroxyapatite, Polycaprolactone, Porosity, Composites, Tissue engineering scaffolds, Mechanical properties |
| Databáze: | OpenAIRE |
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