Lipids and Alzheimer’s Disease
| Autor: | Yuan-Kun Tu, Yu-Chia Kao, Pei-Chuan Ho, I-Ming Jou, Kuen Jer Tsai |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Aging
fats Apolipoprotein B Dietary lipid Review Disease Bioinformatics Catalysis lcsh:Chemistry Inorganic Chemistry Lipid peroxidation chemistry.chemical_compound Membrane Microdomains Alzheimer Disease Lipidomics Animals Humans Medicine Physical and Theoretical Chemistry lcsh:QH301-705.5 Molecular Biology Lipid raft Spectroscopy Brain function biology business.industry Fatty Acids Organic Chemistry Brain General Medicine Lipid Metabolism medicine.disease Lipids Computer Science Applications cholesterols lcsh:Biology (General) lcsh:QD1-999 chemistry Blood-Brain Barrier biology.protein lipidomics lipids (amino acids peptides and proteins) Alzheimer's disease business |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 21, Iss 4, p 1505 (2020) |
| ISSN: | 1422-0067 |
| Popis: | Lipids, as the basic component of cell membranes, play an important role in human health as well as brain function. The brain is highly enriched in lipids, and disruption of lipid homeostasis is related to neurologic disorders as well as neurodegenerative diseases such as Alzheimer’s disease (AD). Aging is associated with changes in lipid composition. Alterations of fatty acids at the level of lipid rafts and cerebral lipid peroxidation were found in the early stage of AD. Genetic and environmental factors such as apolipoprotein and lipid transporter carrying status and dietary lipid content are associated with AD. Insight into the connection between lipids and AD is crucial to unraveling the metabolic aspects of this puzzling disease. Recent advances in lipid analytical methodology have led us to gain an in-depth understanding on lipids. As a result, lipidomics have becoming a hot topic of investigation in AD, in order to find biomarkers for disease prediction, diagnosis, and prevention, with the ultimate goal of discovering novel therapeutics. |
| Databáze: | OpenAIRE |
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