Lung function parameters in omalizumab responder patients: An interesting tool?
| Autor: | C. Nocent, F. Paganin, F. Milhe, J. Attia, Sylvain Marchand-Adam, Laurent Guilleminault, G. Mangiapan, A. Bernady, C. Raspaud, A. Proust, Patrick Berger, F. Pellet, B. Melloni, A. Prudhomme |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Vital capacity medicine.medical_specialty Time Factors Immunology Urology Omalizumab 03 medical and health sciences FEV1/FVC ratio 0302 clinical medicine medicine Humans Immunology and Allergy Lung volumes Anti-Asthmatic Agents 030212 general & internal medicine Residual volume Lung function Aged Retrospective Studies Asthma business.industry Allergic asthma Middle Aged respiratory system medicine.disease Respiratory Function Tests respiratory tract diseases Surgery Treatment Outcome 030228 respiratory system Female business medicine.drug |
| Zdroj: | Allergy. 72:1953-1961 |
| ISSN: | 0105-4538 |
| DOI: | 10.1111/all.13202 |
| Popis: | Background Omalizumab, an anti-IgE antibody, is used to treat patients with severe allergic asthma. The evolution of lung function parameters over time and the difference between omalizumab responder and nonresponder patients remain inconclusive. The objective of this real-life study was to compare the changes in forced expiratory volume in 1 second (FEV1) of omalizumab responders and nonresponders at 6 months. Methods A multicenter analysis was performed in 10 secondary and tertiary institutions. Lung function parameters (forced vital capacity (FVC), pre- and postbronchodilator FEV1, residual volume (RV), and total lung capacity (TLC) were determined at baseline and at 6 months. Omalizumab response was assessed at the 6-month visit. In the omalizumab responder patients, lung function parameters were also obtained at 12, 18, and 24 months. Results Mean prebronchodilator FEV1 showed improvement in responders at 6 months, while a decrease was observed in nonresponders (+0.2±0.4 L and −0.1±0.4 L, respectively, P |
| Databáze: | OpenAIRE |
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