ACUTE AND LATE TOXICITY WITH CHEMORADIOTHERAPY FOR OROPHARYNGEAL CANCER DEPENDING ON THE FRACTIONATION OPTION

Autor:	L. B. Parkhomenko
Rok vydání:	2018
Předmět:	Oncology medicine.medical_specialty business.industry lcsh:R lcsh:Medicine Cancer acute and late toxicity Fractionation medicine.disease Late toxicity cancer of oropharyngeal zone Internal medicine altered fractionation radiotherapy medicine business Chemoradiotherapy
Zdroj:	Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, Vol 16, Iss 6, Pp 679-684 (2018)
ISSN:	2413-0109 2221-8785
DOI:	10.25298/2221-8785-2018-16-6-679-684
Popis:	Background: Chemoradiotherapy fractionation regimen has been developed to reduce the frequency and severity of acute and late toxicity of normal tissues. Purpose: To reduce the incidence and severity of acute and late toxicity in patients with cancer of the oropharyngeal zone stages III-IVA, B by using chemoradiotherapy with dynamic accelerated hyperfractionation with concomitant boost. Material and methods: The data of 280 patients with squamous cell carcinoma of the oral cavity, tongue, oropharynx and hypopharynx stages III-IVA, B were analyzed. In the main group the altered fractionation radiotherapy was conducted. In the control group conventional radiotherapy was used. A comparative evaluation of the effectiveness of radiotherapy with conventional and altered fractionation regimens was conducted. Results of research: In the main group, grade 2 (63,6%) acute oral mucosa toxicity predominated, and in the control group grades 3 (47,5%) and 2 (41,6%) (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ac09084b6b46a1822c26c6c3864388 https://doi.org/10.25298/2221-8785-2018-16-6-679-684 Zobrazit plný text záznamu