Dietary fat intake and risk of epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition

Autor:	Hendrik B. Bueno-de-Mesquita, Konstantinos K. Tsilidis, Guy Fagherazzi, N. Charlotte Onland-Moret, Pagona Lagiou, Eva Lundin, José María Huerta Castaño, Annika Idahl, Petra H.M. Peeters, Louise Hansen, Kay-Tee Khaw, Esther Molina-Montes, Heiner Boeing, Melissa A. Merritt, Saioa Chamosa, Ruth C. Travis, Emily Sonestedt, Sabina Sieri, Elio Riboli, Jennifer Ose, Marc J. Gunter, Annika Steffen, Antonia Trichopoulou, Laura Baglietto, J. Ramón Quirós, Anette Hjartåker, Inger T. Gram, Elisabete Weiderpass, Kim Overvad, Dimitrios Trichopoulos, Eva Ardanaz, Mireia Obón-Santacana, Anne Tjønneland, Laure Dossus, Rosario Tumino, Giovanna Masala, Amalia Mattiello, Carlotta Sacerdote, Nicholas J. Wareham, Veronique Chajes, Isabelle Romieu, Sabina Rinaldi, Renée T. Fortner
Rok vydání:	2014
Předmět:	Oncology Cancer Research endocrine system diseases Epidemiology Saturated fat Carcinoma Ovarian Epithelial DISEASE Polyunsaturated fat Serous neoplasms Neoplasms REPRODUCIBILITY Neoplasms Glandular and Epithelial Prospective Studies Unsaturated dietary fats Prospective cohort study Dietary fats Ovarian cancer Adult Dietary Fats Dietary Fats Unsaturated Female Follow-Up Studies Humans Middle Aged Multivariate Analysis Ovarian Neoplasms Proportional Hazards Models Risk Public Environmental & Occupational Health Unsaturated Hazard ratio Glandular and Epithelial WOMEN female genital diseases and pregnancy complications European Prospective Investigation into Cancer and Nutrition Quartile FOOD-FREQUENCY QUESTIONNAIRE HEALTH Life Sciences & Biomedicine medicine.medical_specialty RELATIVE VALIDITY NUTRIENT INTAKE Breast cancer Internal medicine medicine BREAST-CANCER COHORT METAANALYSIS Science & Technology Proportional hazards model business.industry medicine.disease Endocrinology business
Zdroj:	Merritt, M A, Riboli, E, Weiderpass, E, Tsilidis, K K, Overvad, K, Tjønneland, A, Hansen, L, Dossus, L, Fagherazzi, G, Baglietto, L, Fortner, R T, Ose, J, Steffen, A, Boeing, H, Trichopoulou, A, Trichopoulos, D, Lagiou, P, Masala, G, Sieri, S, Mattiello, A, Tumino, R, Sacerdote, C, Bueno-de-Mesquita, H B A, Onland-Moret, N C, Peeters, P H, Hjartåker, A, Gram, I T, Quirós, J R, Obón-Santacana, M, Molina-Montes, E, Huerta Castaño, J M, Ardanaz, E, Chamosa, S, Sonestedt, E, Idahl, A, Lundin, E, Khaw, K-T, Wareham, N, Travis, R C, Rinaldi, S, Romieu, I, Chajes, V & Gunter, M J 2014, ' Dietary fat intake and risk of epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition ', Cancer epidemiology, vol. 38, no. 5, pp. 528-37 . https://doi.org/10.1016/j.canep.2014.07.011 Merritt, M A, Riboli, E, Weiderpass, E, Tsilidis, K K, Overvad, K, Tjønneland, A, Hansen, L, Dossus, L, Fagherazzi, G, Baglietto, L, Fortner, R T, Ose, J, Steffen, A, Boeing, H, Trichopoulou, A, Trichopoulos, D, Lagiou, P, Masala, G, Sieri, S, Mattiello, A, Tumino, R, Sacerdote, C, Bueno-de-Mesquita, H B, Onland-Moret, N C, Peeters, P H, Hjartåker, A, Gram, I T, Quirós, J R, Obón-Santacana, M, Molina-Montes, E, Huerta Castaño, J M, Ardanaz, E, Chamosa, S, Sonestedt, E, Idahl, A, Lundin, E, Khaw, K T, Wareham, N, Travis, R C, Rinaldi, S, Romieu, I, Chajes, V & Gunter, M J 2014, ' Dietary fat intake and risk of epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition ', Cancer epidemiology, vol. 38, no. 5, pp. 528-537 . https://doi.org/10.1016/j.canep.2014.07.011
ISSN:	1877-7821
DOI:	10.1016/j.canep.2014.07.011
Popis:	There are inconsistent and limited data available to assess the relationship between fat intake and risk of epithelial ovarian cancer (EOC). We examined the consumption of total fat, fat sources and fat subtypes in relation to risk of EOC and its major histologic subtypes in the European Prospective Investigation into Cancer and Nutrition which includes incident invasive (n=1095) and borderline (n=96) EOC. Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). In multivariate models, we observed no association with consumption of total fat, animal or plant fat, saturated fat, cholesterol, monounsaturated fat, or fatty fish and risk of invasive EOC. There was, however, an increased risk of invasive EOC in the highest category of intake (Quartile 4 vs. Quartile 1) of polyunsaturated fat (HR=1.22, 95% CI=1.02-1.48, Ptrend=0.02). We did not observe heterogeneity in the risk associations in comparisons of serous and endometrioid histologic subtypes. This study does not support an etiological role for total fat intake in relation to EOC risk; however, based on observations of a positive association between intake of polyunsaturated fat and invasive EOC risk in the current and previous studies, this fat subtype warrants further investigation to determine its potential role in EOC development.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81aad3cd0da1b63065d9079d80020b14 https://doi.org/10.1016/j.canep.2014.07.011 Zobrazit plný text záznamu Full Text from ScienceDirect