Exploiting ECM remodelling to promote immune-mediated tumour destruction
| Autor: | Awen Gallimore, Ana Pires, Stephanie E A Burnell |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Antigenicity
T cell medicine.medical_treatment T-Lymphocytes Immunology Biology Cancer treatment Extracellular Matrix Extracellular matrix medicine.anatomical_structure Immune system Cancer immunotherapy Tumour destruction Neoplasms Cancer research medicine Tumor Microenvironment Immunology and Allergy Humans Immunotherapy |
| ISSN: | 0952-7915 |
| Popis: | Cancer immunotherapy represents a significant breakthrough in cancer treatment mainly due to the ability to harness the activities of cancer-specific T cells. Despite this, most cancers remain resistant to T cell attack. Many reasons have been proposed to explain this, ranging from a lack of antigenicity through to the immunosuppressive effects of the tumour microenvironment. In this review, we examine the relationship between the immune system and a key component of the tumour microenvironment, namely the extracellular matrix (ECM). Specifically, we explore the reciprocal effects of immune cells and the tumour ECM and how the processes underpinning this relationship act to either promote or restrain tumour progression. |
| Databáze: | OpenAIRE |
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