Low density lipoprotein receptor-related protein 5 gene polymorphisms and osteoporosis in Thai menopausal women
| Autor: | Benjaluck Phonrat, Hathairad Hananantachai, Rungsunn Tungtrongchitr, Sangchai Preutthipan, Anong Kitjaroentham |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Linkage disequilibrium Osteoporosis 030209 endocrinology & metabolism Single-nucleotide polymorphism Polymorphism Single Nucleotide General Biochemistry Genetics and Molecular Biology Linkage Disequilibrium 03 medical and health sciences Pharmacology Toxicology and Pharmaceutics(all) 0302 clinical medicine Bone Density Risk Factors Internal medicine medicine Humans Genetic Predisposition to Disease Menopausal Thai women General Pharmacology Toxicology and Pharmaceutics Allele frequency Genetic Association Studies Aged Low density lipoprotein receptor-related protein 5 (LRP5) Medicine(all) business.industry Osteopenia Biochemistry Genetics and Molecular Biology(all) Research Haplotype General Medicine Odds ratio Middle Aged medicine.disease Thailand 030104 developmental biology Endocrinology Logistic Models Low Density Lipoprotein Receptor-Related Protein-5 Haplotypes Female Menopause business Body mass index Coding single nucleotide polymorphisms |
| Zdroj: | Journal of Negative Results in Biomedicine |
| ISSN: | 1477-5751 |
| DOI: | 10.1186/s12952-016-0059-7 |
| Popis: | Background Osteoporosis, characterized by low bone mineral density (BMD) and high bone fracture risk, is prevalent in Thai menopausal women. Genetic factors are known to play a key role in BMD. Low density lipoprotein receptor-related protein 5 (LRP5), a co-receptor in the Wnt/beta-catenin pathway, is involved in many aspects of bone biology. As coding single nucleotide polymorphisms (cSNPs) of LRP5, including A1330V (rs3736228), and Asian-related Q89R (rs41494349) and N740N (rs2306862), are associated with lowered BMD, this study aimed to determine the relationship between these LRP5 polymorphisms and BMD in 277 Thai menopausal women. Results Only rs3736228 deviated from the Hardy–Weinberg equilibrium of allele frequency (p = 0.022). The median, range and p value for the BMD related to each SNP parameter were compared (Mann–Whitney U test). Significant differences were observed between wild-type and risk alleles for both rs3736228 (total radial, p = 0.011; and radial 33, p = 0.001) and rs2306862 (radial 33: p = 0.015) SNPs, with no significant difference for rs41494349 SNP. Linkage disequilibrium was strong for both rs3736228 and rs2306862 SNPs. Haplotype analysis identified high CC frequency in both normal and osteopenia/osteoporosis groups, with a significant odds ratio for carrying the TT haplotype; however, this was non-significant after adjusting for age. Multivariate binary logistic regression analysis performed for rs3736228 showed that individuals with a body mass index |
| Databáze: | OpenAIRE |
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