Tumor ablation using low-intensity ultrasound and sound excitable drug
| Autor: | Myung Shin Han, Ching-Hsuan Tung, Young Tai Kim, Brian E. O'Neill, Jianjun Qi |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Pathology
medicine.medical_specialty Materials science Ultrasonic Therapy Mice Nude Pharmaceutical Science Antineoplastic Agents Breast Neoplasms 02 engineering and technology Article Tumor ablation Cell membrane Mice 03 medical and health sciences 0302 clinical medicine Low intensity ultrasound Cell Line Tumor medicine Animals Humans Ultrasound energy Sound (medical instrument) Mice Inbred BALB C Rose Bengal business.industry Sonodynamic therapy Ultrasound 021001 nanoscience & nanotechnology Combined Modality Therapy Membrane medicine.anatomical_structure Xanthenes 030220 oncology & carcinogenesis Female 0210 nano-technology business Biomedical engineering |
| Zdroj: | Journal of Controlled Release. 258:67-72 |
| ISSN: | 0168-3659 |
| Popis: | The cell membrane is a semi-fluid container that defines the boundary of cells, and provides an enclosed environment for vital biological processes. A sound excitable drug (SED) that is non-cytotoxic to cells is developed to disrupt the plasma membrane under gentle ultrasound insonation, 1 MHz, 1 W/cm2. The frequency and power density of insonation are within the physical therapy and medical imaging windows; thus the applied ultrasound is safe and not harmful to tissues. The insertion of SEDs into the plasma membrane is not toxic to cells; however, the intruding SEDs weaken the membrane's integrity. Under insonation, the ultrasound energy destabilized the SED disrupted membranes, resulting in membrane rupture and eventual cell death. In a xenograft breast tumor model, the SED alone or the ultrasound alone caused little adverse effects to tumor tissue, while the combined treatment triggered necrosis with a brief local insonation of 3 min. The described sono-membrane rupture therapy could be a safe alternative to the currently used high-energy tissue ablation technology, which uses X-rays, gamma rays, electron beams, protons, or high-intensity focused ultrasound. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect