Population pharmacokinetics of cabotegravir following administration of oral tablet and long‐acting intramuscular injection in adult HIV‐1‐infected and uninfected subjects
| Autor: | Kelong Han, Mark Baker, Mark Lovern, Prokash Paul, Yuan Xiong, Parul Patel, Katy P. Moore, Ciara S. Seal, Amy G. Cutrell, Ronald D. D'Amico, Paul D. Benn, Raphael J. Landovitz, Mark A. Marzinke, William R. Spreen, Susan L. Ford |
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| Rok vydání: | 2022 |
| Předmět: |
Adult
Pyridones HIV Infections Diketopiperazines Injections Intramuscular Injections population pharmacokinetics Clinical Research Humans Pharmacology (medical) Pharmacology & Pharmacy Pharmacology Intramuscular Likelihood Functions cabotegravir HIV integrase inhibitor Evaluation of treatments and therapeutic interventions long-acting Pharmacology and Pharmaceutical Sciences 6.1 Pharmaceuticals HIV-1 Female Infection Tablets |
| Zdroj: | British journal of clinical pharmacology, vol 88, iss 10 |
| ISSN: | 1365-2125 0306-5251 |
| Popis: | AimTo characterize cabotegravir population pharmacokinetics using data from phase 1, 2 and 3 studies and evaluate the association of intrinsic and extrinsic factors with pharmacokinetic variability.MethodsAnalyses were implemented in NONMEM and R. Concentrations below the quantitation limit were modelled with likelihood-based approaches. Covariate relationships were evaluated using forward addition (P |
| Databáze: | OpenAIRE |
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