Synchronized Biventricular Heart Pacing in a Closed-chest Porcine Model based on Wirelessly Powered Leadless Pacemakers
| Autor: | Aydin Babakhani, Hongming Lyu, Mathews John, Allison Post, Brian Greet, David Burkland, Mehdi Razavi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Cardiac function curve
medicine.medical_specialty Swine medicine.medical_treatment Cardiac resynchronization therapy lcsh:Medicine Bioengineering 02 engineering and technology 030204 cardiovascular system & hematology Cardiovascular Article 03 medical and health sciences Electrocardiography 0302 clinical medicine Electric Power Supplies Internal medicine 0202 electrical engineering electronic engineering information engineering Medicine Animals Cardiac Resynchronization Therapy Devices Ventricular dyssynchrony Author Correction lcsh:Science Cardiac device therapy Multidisciplinary medicine.diagnostic_test business.industry Animal 020208 electrical & electronic engineering lcsh:R Equipment Design medicine.disease External source Electrical and electronic engineering Defibrillators Implantable Disease Models Animal Heart Disease Safety regulation Power consumption Disease Models Cardiology Female lcsh:Q Implantable business Wireless Technology Defibrillators |
| Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020) Scientific Reports Scientific reports, vol 10, iss 1 |
| ISSN: | 2045-2322 |
| Popis: | About 30% of patients with impaired cardiac function have ventricular dyssynchrony and seek cardiac resynchronization therapy (CRT). In this study, we demonstrate synchronized biventricular (BiV) pacing in a leadless fashion by implementing miniaturized and wirelessly powered pacemakers. With their flexible form factors, two pacemakers were implanted epicardially on the right and left ventricles of a porcine model and were inductively powered at 13.56 MHz and 40.68 MHz industrial, scientific, and medical (ISM) bands, respectively. The power consumption of these pacemakers is reduced to µW-level by a novel integrated circuit design, which considerably extends the maximum operating distance. Leadless BiV pacing is demonstrated for the first time in both open-chest and closed-chest porcine settings. The clinical outcomes associated with different interventricular delays are verified through electrophysiologic and hemodynamic responses. The closed-chest pacing only requires the external source power of 0.3 W and 0.8 W at 13.56 MHz and 40.68 MHz, respectively, which leads to specific absorption rates (SARs) 2–3 orders of magnitude lower than the safety regulation limit. This work serves as a basis for future wirelessly powered leadless pacemakers that address various cardiac resynchronization challenges. |
| Databáze: | OpenAIRE |
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