Multi-modality management of craniopharyngioma: a review of various treatments and their outcomes
| Autor: | Richard P. Moser, John M. Varlotto, Paul Rava, Heath B. Mackley, Matt Pavelic, Dan Nguyen, Charles A. Specht, Jonathan Glanzman, Urvashi Upadhyay, Christopher Dimaio, Jonas M. Sheehan, Steven Sogge, Shakeeb Yunus, Clemens Grassberger, Matthew Tangel, Cheng Saw, Michael Glantz, Thomas J. Fitzgerald |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.medical_treatment Medicine (miscellaneous) Articles medicine.disease Craniopharyngioma Radiosurgery Multi modality Radiation therapy 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis medicine Adjuvant therapy Cyst Radiology Radiation treatment planning business Proton therapy 030217 neurology & neurosurgery |
| Zdroj: | Neuro-Oncology Practice. 3:173-187 |
| ISSN: | 2054-2585 2054-2577 |
| DOI: | 10.1093/nop/npv029 |
| Popis: | Craniopharyngioma is a rare tumor that is expected to occur in ∼400 patients/year in the United States. While surgical resection is considered to be the primary treatment when a patient presents with a craniopharyngioma, only 30% of such tumors present in locations that permit complete resection. Radiotherapy has been used as both primary and adjuvant therapy in the treatment of craniopharyngiomas for over 50 years. Modern radiotherapeutic techniques, via the use of CT-based treatment planning and MRI fusion, have permitted tighter treatment volumes that allow for better tumor control while limiting complications. Modern radiotherapeutic series have shown high control rates with lower doses than traditionally used in the two-dimensional treatment era. Intracavitary radiotherapy with radio-isotopes and stereotactic radiosurgery may have a role in the treatment of recurrent cystic and solid recurrences, respectively. Recently, due to the exclusive expression of the Beta-catenin clonal mutations and the exclusive expression of BRAF V600E clonal mutations in the overwhelming majority of adamantinomatous and papillary tumors respectively, it is felt that inhibitors of each pathway may play a role in the future treatment of these rare tumors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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