Retrospective Comparison of Cefdinir, Cephalexin, and Sulfamethoxazole-Trimethoprim in the Treatment of Outpatient Pediatric Urinary Tract Infections

Autor:	Brianna Cardinale, Tracy N Zembles, Katie Ray, Glenn Bushee, Melodee Liegl, Pippa Simpson, Michelle Mitchell
Rok vydání:	2022
Předmět:	Cephalexin Cefdinir Outpatients Trimethoprim Sulfamethoxazole Drug Combination Urinary Tract Infections Pediatrics Perinatology and Child Health Humans Child Retrospective Studies Anti-Bacterial Agents
Zdroj:	Clinical Pediatrics. 62:47-54
ISSN:	1938-2707 0009-9228
DOI:	10.1177/00099228221112055
Popis:	This retrospective single-center study included children aged 2 months to 18 years who were prescribed an oral antibiotic for microbiologically confirmed urinary tract infection (UTI). The primary outcomes were re-encounter to the hospital, emergency department, or urgent care within 30 days and modification of the antibiotic regimen within 14 days. Development of Clostridioides difficile ( C difficile) infection or new allergic reaction to the antibiotic prescribed was the secondary outcome. The sample included 2685 children. Rates of re-encounter were similar regardless of the initial antibiotic prescribed ( P = .88), and patients who received cefdinir had a lower rate of medication changes (5%) compared with both cephalexin (14%) and sulfamethoxazole-trimethoprim (15%) ( P ≤ .001). The most common reason for medication change was susceptibility interpretation. Given its low side-effect profile and narrow spectrum compared with the alternatives, cephalexin appears to be a reasonable choice as first-line therapy for the treatment of uncomplicated pediatric UTI.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8199529fd7c29a173a209b10c53157de https://doi.org/10.1177/00099228221112055 Zobrazit plný text záznamu