Comparison of automatic versus manual procedures for the quantification of dopamine D2 receptor availability using I-123-IBZM-SPECT
| Autor: | Felix M. Mottaghy, Oliver H. Winz, Frederik A. Verburg, Manuel Dafotakis, Siamak Mohammadkhani Shali, A. Heinzel |
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| Přispěvatelé: | Beeldvorming, MUMC+: DA BV Medische staf (6), RS: FHML non-thematic output |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Striatal dopamine
Hermes BRASS Pyrrolidines IBZM Toolbox manual quantification Parkinsonian syndromes Automation atypical parkinsonian syndromes Dopamine receptor D2 Ibzm spect Medicine Humans Radiology Nuclear Medicine and imaging Reference standards Tomography Emission-Computed Single-Photon IBZM SPECT business.industry Receptors Dopamine D2 Parkinson Disease General Medicine Middle Aged Reference Standards ROC Curve idiopathic Parkinson's syndrome Benzamides Nuclear medicine business Area under the roc curve |
| Zdroj: | Nuclear Medicine Communications, 36(11), 1120-1126. LIPPINCOTT WILLIAMS & WILKINS |
| ISSN: | 0143-3636 |
| Popis: | Introduction I-123-IBZM-SPECT is often used to differentiate between idiopathic Parkinson's syndrome and atypical parkinsonian syndromes. The aim of this study was to compare three different procedures to quantify the receptor availability of striatal dopamine D2 receptors. (a) Manual quantification performed using individually adjusted volume of interests sets (mVoi). (b) Automatic quantification applying the commercially available Hermes BRASS software (BRASS). (c) Automatic quantification applying the open-source software IBZM Toolbox (TBX).Materials and methods Using the three methods, we analyzed 100 scans. For the mVOI methods, three different investigators (two experienced, one inexperienced) carried out the analysis. We compared the different methods with each other and with the reference standard established by clinical follow-up. The diagnostic performance was assessed by calculating receiver-operating characteristic (ROC) curves.Results Correlation analyses resulted in the following: mVOI versus BRASS (r(2)=0.694) (P |
| Databáze: | OpenAIRE |
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