Comparison of time-action profiles of insulin glargine and NPH insulin in normal and diabetic dogs
| Autor: | Y. Kanaya, T. Motoike, Toshinori Sako, Hisashi Mizutani, Peter Lee, Hiroko Fukuta, Akihiro Mori, Toshiro Arai, K. Iwase |
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| Rok vydání: | 2007 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Time Factors medicine.medical_treatment Insulin Isophane Insulin Glargine NPH insulin Hypoglycemia Diabetes Mellitus Experimental Lethal Dose 50 Dogs Internal medicine Diabetes mellitus medicine Animals Insulin Dog Diseases Glycemic General Veterinary business.industry Insulin glargine INSULIN PREPARATIONS General Medicine medicine.disease Insulin Long-Acting Endocrinology Insulin dependent diabetes Female business medicine.drug |
| Zdroj: | Veterinary research communications. 32(7) |
| ISSN: | 0165-7380 |
| Popis: | Intermediate insulin injections are commonly used for glycemic control in insulin dependent diabetic dogs acting as a replacement for natural insulin. Neutral Protamin Hagedorn (NPH) insulin and insulin glargine are two types of injectable insulin preparations commonly used in humans. In our study, we investigated the time-action profiles of both aforementioned insulin preparations in normal dogs in order to determine whether co-administration of NPH and glargine would be of benefit to insulin dependent diabetic dogs as it is for humans suffering from insulin dependent diabetes. Time-action profiles of NPH insulin and insulin glargine in normal dogs demonstrated a clear difference between both insulin preparations confirming that NPH insulin is an intermediate-acting preparation whereas insulin glargine is a long-lasting preparation. In addition, co-administration of NPH insulin and insulin glargine resulted in tight glycemic control as compared to NPH insulin alone in insulin dependent diabetic dogs. However, co-administration result in hypoglycemia at the dosages tested. |
| Databáze: | OpenAIRE |
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