Peripheral tissue chemokines: homeostatic control of immune surveillance T cells
| Autor: | Michelle L. McCully, Bernhard Moser, Ariadni Kouzeli |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cellular immunity Chemokine T-Lymphocytes Immunology Cell Disease 03 medical and health sciences 0302 clinical medicine Immune system Cell Movement Skin Physiological Phenomena medicine Immunology and Allergy Animals Homeostasis Humans Receptor Immunologic Surveillance Skin biology Immunity biochemical phenomena metabolism and nutrition 030104 developmental biology medicine.anatomical_structure Cellular Microenvironment Organ Specificity Immune System biology.protein Receptors Chemokine Chemokines Neuroscience Immunologic Memory Function (biology) 030215 immunology Signal Transduction |
| ISSN: | 1471-4906 |
| Popis: | Cellular immunity is governed by a complex network of migratory cues that enable appropriate immune cell responses in a timely and spatially controlled fashion. This review focuses on the chemokines and their receptors regulating the steady-state localisation of immune cells within healthy peripheral tissues. Steady-state immune cell traffic is not well understood but is thought to involve constitutive (homeostatic) chemokines. The recent discovery of tissue-resident memory T cells (TRM cells) illustrates our need for understanding how chemokines control immune cell mobilisation and/or retention. These studies will be critical to unravel novel pathways for preserving tissue function (aging) and preventing tissue disease (vaccination). |
| Databáze: | OpenAIRE |
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