Human ligands of the Notch receptor
| Autor: | Spyros Artavanis-Tsakonas, John Leiman, Domingos Henrique, Amy Banks, Efthimios Mitsiadis, David C. Ward, David Ish-Horowitz, Grace E. Gray, Maria Louisa Carcangiu, Robert S. Mann |
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| Rok vydání: | 1999 |
| Předmět: |
Cell type
Molecular Sequence Data Notch signaling pathway Uterine Cervical Neoplasms In situ hybridization Cervix Uteri Biology medicine.disease_cause Pathology and Forensic Medicine Reference Values medicine Humans Serrate-Jagged Proteins Amino Acid Sequence Cloning Molecular CADASIL Calcium-Binding Proteins Intracellular Signaling Peptides and Proteins Chromosome Mapping Membrane Proteins Proteins medicine.disease Blotting Northern Cell biology Notch proteins Hes3 signaling axis Immunology Cyclin-dependent kinase 8 Intercellular Signaling Peptides and Proteins Female Jagged-2 Protein Carcinogenesis Carrier Proteins Jagged-1 Protein Regular Articles |
| Zdroj: | Scopus-Elsevier Ciência Vitae ResearcherID |
| ISSN: | 0002-9440 |
| Popis: | During development, the Notch signaling pathway is essential for the appropriate differentiation of many cell types in organisms across the phylogenetic scale, including humans. Notch signaling is also implicated in human diseases, including a leukemia and two hereditary syndromes known as Alagille and CADASIL. To generate tools for pursuing the role of the Notch pathway in human disease and development, we have cloned and analyzed the expression of three human homologues of the Notch ligands Delta and Serrate, human Jagged1 (HJ1), human Jagged2 (HJ2), and human Delta1 (H-Delta-1), and determined their chromosomal localizations. We have also raised antibodies to HJ1, and used these antibodies in conjunction with in situ hybridization to examine the expression of these ligands in normal and cancerous cervical tissue. We find that, as reported previously for Notch, the ligands are up-regulated in certain neoplastic tissues. This observation is consistent with the notion that Notch signaling is an important element in these pathogenic conditions, raising the possibility that modulation of Notch activity could be used to influence the fate of the cells and offering a conceivable therapeutic avenue. |
| Databáze: | OpenAIRE |
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