Optimization of Solid Phase Microextraction Procedure for Determination of Paraquat Using Reduction Process
| Autor: | Marzieh Torabbeigi, Seyed Jamaleddin Shahtaheri, Fateme Ghavidel, Abbas Rahimi Froushani |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Detection limit
Chromatography Calibration curve General Chemical Engineering 010401 analytical chemistry Urine Mass spectrometry Solid-phase microextraction 01 natural sciences Chloride 0104 chemical sciences Analytical Chemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Paraquat chemistry medicine Gas chromatography–mass spectrometry 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Журнал аналитической химии. 71:681-685 |
| ISSN: | 0044-4502 |
| DOI: | 10.7868/s0044450216070082 |
| Popis: | Headspace solid phase microextraction (HS-SPME) followed by gas chromatography–mass spectrometry was developed for the determination of paraquat in urine. The volatile product resulting from reduction of paraquat by sodium borohydride–nickel chloride was used for HS-SPME. The calibration curve was linear from 10–1000 ng/mL and the limit of detection was 0.1 ng/mL. The optimized methods were validated using 500 and 750 ng/mL concentrations of paraquat in the spiked urine samples. The recoveries obtained in this study were 98.2% for intra-day (n = 6) and 99.2% for inter-day (n = 6), respectively, with RSD lower than 1.1%. |
| Databáze: | OpenAIRE |
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