Oligodendrogliomas Lacking O6-Methylguanine-DNA-Methyltransferase Expression
| Autor: | P. Mennonna, N. Di Lorenzo, Franco Ammannati, Gianluigi Taddei, Luisa Arganini, Annamaria Buccoliero, Pasquale Gallina |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty DNA Repair DNA repair Oligodendroglioma Antineoplastic Agents Nitrosourea Compounds O(6)-Methylguanine-DNA Methyltransferase medicine Humans Neoplasm Pharmacology (medical) Oligodendroglial Tumor neoplasms Survival analysis Aged Pharmacology Brain Neoplasms business.industry Gene Expression Profiling O-6-methylguanine-DNA methyltransferase Lomustine Middle Aged medicine.disease Immunohistochemistry Survival Analysis digestive system diseases Infectious Diseases Oncology Drug Resistance Neoplasm Cancer research Female Glioblastoma business medicine.drug |
| Zdroj: | Journal of Chemotherapy. 17:321-326 |
| ISSN: | 1973-9478 1120-009X |
| DOI: | 10.1179/joc.2005.17.3.321 |
| Popis: | O6-Methylguanine-DNA-Methyltransferase (MGMT) is a DNA repair protein considered to be a chemosensitivity predictor. We evaluated the immunohistochemical MGMT expression in 28 consecutive oligodendroglial tumors (21 oligodendrogliomas, 5 mixed oligoastrocytomas, and 2 glioblastomas with prominent oligodendroglial features; 13 treated with CCNU) and compared it with that of 13 glioblastomas. Twenty-six (93%) oligodendroglial tumors were MGMT-negative, 2 (7%) were MGMT-positive. Twelve (92%) patients treated with CCNU had MGMT-negative lesions and their median survival was 73 months; 1 patient had an MGMT-positive oligodendroglioma and is alive at 28 months. Three (23%) glioblastomas were MGMT-negative and 10 (77%) MGMT-positive. The lower MGMT expression in oligodendroglial tumors compared to glioblastomas (P < 0.05), which have different chemosensitivity, suggests a possible role of MGMT in the determination of chemoresistance. Nevertheless, the heterogeneous outcome of our MGMT-negative oligodendroglial tumors treated with CCNU, indicates that MGMT expression alone is insufficient to predict the response to alkylating drugs, presumably because of the numerous mechanisms involved. |
| Databáze: | OpenAIRE |
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