Neural stem cell transplantation for the treatment of primary torsion dystonia: A case report
| Autor: | Josefin Adlerberth, Feng Yin, Ying‑Kui Liang, Zeng‑Min Tian, Jian‑Ning Zhang, Wang‑Sheng Lu, Wen‑Qing Ren |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty primary torsion spasm Stereotactic surgery torsion dystonia-1 03 medical and health sciences frameless stereotactic surgery 0302 clinical medicine Immunology and Microbiology (miscellaneous) medicine Brain positron emission tomography Stroke neural stem cells Dystonia medicine.diagnostic_test business.industry Cancer Magnetic resonance imaging General Medicine Articles medicine.disease Neural stem cell Surgery nervous system diseases Transplantation 030104 developmental biology business 030217 neurology & neurosurgery transplantation |
| Zdroj: | Experimental and Therapeutic Medicine |
| ISSN: | 1792-0981 |
| Popis: | Primary torsion dystonia (PTD) occurs due to a genetic mutation and often advances gradually. Currently, there is no therapy available that is able to inhibit progression. Neural stem cells (NSCs) are being investigated as potential therapies for neurodegenerative diseases, such as stroke and trauma. The present study evaluated the clinical effectiveness of NSC transplantation in an 18-year-old male patient with PTD, to assess the ability of this therapy to inhibit PTD progression. Genetic testing of the patient revealed a mutation in the torsion dystonia-1 (DYT1) gene (907-909 delGAG). NSCs were bilaterally implanted in the globus pallidus of the patient through stereotactic surgery. Prior to surgery, the patient's Burke-Fahn-Marsden dystonia movement score (BFMDMS) was 21, which progressively decreased after surgery to 18, 17, 15 and 13 at 1, 2, 3 and 4 postoperative years, respectively. BFMDMS was improved by 38.1% over the 4 postoperative years. Although computed tomography and magnetic resonance imaging examinations showed no significant changes prior to and following surgery, postoperative brain positron emission tomography scans revealed increased glucose metabolism in the transplanted region. The clinical efficacy of NSC transplantation in this patient suggests its potential for the treatment of DYT1-positive patients with PTD. |
| Databáze: | OpenAIRE |
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