Association Between Pre-Transplant Magnesemia and Post-Transplant Dysglycemia in Kidney Transplant Recipients
| Autor: | Seyed Mansour Gatmiri, Azam Alamdari, Saba Heydari Seradj, Ghazal Asadi, M R Khatami, Farzaneh Sadat Minoo, Simin Dashti-Khavidaki, Neda Naderi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
business.industry Endocrinology Diabetes and Metabolism Magnesemia Serum Magnesium 030209 endocrinology & metabolism medicine.disease Impaired fasting glucose Gastroenterology Kidney Transplantation Hypomagnesemia Transplantation 03 medical and health sciences 0302 clinical medicine surgical procedures operative Diabetes mellitus Internal medicine medicine Impaired Fasting Glucose 030212 general & internal medicine Risk factor business Kidney transplantation Glycemic Research Article |
| Zdroj: | International Journal of Endocrinology and Metabolism |
| ISSN: | 1726-9148 1726-913X |
| Popis: | Background Serum magnesium (Mg) status in kidney transplant recipients has been a center of attention in the past few years. Current evidence suggests an association between pre-transplant hypomagnesemia and post-transplant hyperglycemia. Objective The purpose of this study was to assess the associations of pre-transplant magnesemia with blood glucose disturbances within 6 months post-kidney transplantation. Methods In this retrospective cohort, 89 first-time kidney transplant recipients with 6 months of follow-up were included. None of the participants had a positive history of rejection, pre-transplant history of diabetes mellitus or fasting plasma glucose ≥ 100 mg/dL. Results Post-transplant diabetes mellitus (PTDM) and impaired fasting glucose (IFG) 6 months post-transplant was found in 7.9% and 41.6% of the study group, respectively. The mean pre-transplant serum Mg level was 1.92 ± 0.30 mg/dL in the study population (n = 89), and it was significantly lower in IFG (n = 37) and IFG/PTDM (n = 44) groups compared to normoglycemic (n = 45) recipients (1.83 ± 0.31 mg/dL vs. 2.00 ± 0.27 mg/dL, P = 0.008, and 1.84 ± 0.31 mg/dL vs. 2.00 ± 0.27 mg/dL, P = 0.012, respectively). Patients with serum Mg less than 1.9 mg/dL were nearly 2.6 times more likely to develop IFG or IFG/PTDM within 6 months post-transplant (P = 0.044 and P = 0.040, respectively). Conclusions Pre-transplant hypomagnesemia may be considered a risk factor for developing post-transplant glycemic disturbances, and patients with lower pre-transplant Mg concentration could be at a higher risk for developing IFG. |
| Databáze: | OpenAIRE |
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