Prevalence, Characteristics, and One-Year Follow-Up of Congenital Cytomegalovirus Infection in Isfahan City, Iran
| Autor: | Hamid Rahimi, Pegah Karimian, Majid Mohammadizadeh, Omid Yaghini, Hossein Nasr Azadani, atosa adibi, Seyed Ali Mohammad Arabzadeh |
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| Rok vydání: | 2016 |
| Předmět: |
Microbiology (medical)
Pediatrics medicine.medical_specialty Article Subject One year follow up Hearing loss Birth weight Congenital cytomegalovirus infection Urine Disease Microbiology lcsh:Infectious and parasitic diseases 03 medical and health sciences 0302 clinical medicine 030225 pediatrics Virology Medicine Seroprevalence lcsh:RC109-216 030212 general & internal medicine Prospective cohort study business.industry virus diseases medicine.disease Infectious Diseases Parasitology medicine.symptom business Research Article |
| Zdroj: | Interdisciplinary Perspectives on Infectious Diseases Interdisciplinary Perspectives on Infectious Diseases, Vol 2016 (2016) |
| ISSN: | 1687-7098 1687-708X |
| DOI: | 10.1155/2016/7812106 |
| Popis: | Introduction.Need of neonatal screening forCytomegalovirus(CMV) infection is under debate, in part because of limited data on importance of the disease regarding the prevalence of congenital CMV (cCMV) infection and associated morbidity and mortality. We aimed to evaluate the prevalence and prognosis of cCMV infection in Iran, where there is high maternal seroprevalence of CMV.Methodology. This prospective study was conducted in Isfahan city, Iran, from 2014 to 2016. CMV was investigated in urine specimens by using the real-time polymerase chain reaction (RT-PCR) method. CMV-infected infants were examined for clinical and laboratory findings attributed to CMV infection and followed up for one year.Results.Among 1617 studied neonates, eight (0.49%) were positive for CMV infection. CMV-infected neonates were more likely to be preterm than noninfected ones (25% versus 4.5%,p=0.0508), and they had lower birth weight. Three out of the eight CMV-infected neonates had transient symptoms at birth. At follow-up, one case had mild hearing loss. Most patients had impaired growth during the one-year follow-up.Conclusions.The primary object of this study was determination of prevalence of cCMV infection in Iran as a developing country, which was at the lower range compared with other such countries. cCMV infection may result in short-term impairment in growth. |
| Databáze: | OpenAIRE |
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