Readily tunable and bifunctional L-prolinamide derivatives: design and application in the direct enantioselective Aldol reactions
| Autor: | Wen-Jing Xiao, Xin-Yong Li, Jian Wan, Lin Cheng, Jia-Rong Chen, Hai-Hua Lu |
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| Rok vydání: | 2005 |
| Předmět: |
Aldehydes
Molecular Structure Proline Cyclohexanones Organic Chemistry Enantioselective synthesis Cyclohexanone Stereoisomerism General Medicine Biochemistry Combinatorial chemistry Catalysis chemistry.chemical_compound chemistry Aldol reaction Drug Design Carbonyl derivatives Organic chemistry Molecule Physical and Theoretical Chemistry Bifunctional |
| Zdroj: | Organic letters. 7(20) |
| ISSN: | 1523-7060 |
| Popis: | [reaction: see text] Readily tunable and bifunctional L-prolinamides as novel organocatalysts have been developed, and their catalytic activities were evaluated in the direct asymmetric Aldol reactions of various aromatic aldehydes and cyclohexanone. High isolated yields (up to 94%), enantioselectivities (up to 99% ee), and anti-diastereoselectivities (up to 99:1) were obtained under the optimal conditions. |
| Databáze: | OpenAIRE |
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