How many neutrophils are enough (redux, redux)?
| Autor: | Samuel C. Silverstein, Raul Rabadan |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
FOS: Computer and information sciences
Pathology medicine.medical_specialty Neutropenia Neutrophil bactericidal activity Dynamic system model Neutrophils Bioinformatics business.industry General Medicine Medical sciences medicine.disease Medicine--Research Immunology medicine Medicine business Biomedical sciences |
| Zdroj: | Journal of Clinical Investigation. 122:2776-2779 |
| ISSN: | 0021-9738 |
| Popis: | Many chemotherapeutic regimens produce neutropenia, which predisposes to microbial infection. However, not all neutropenic individuals develop infections, so the ability to predict this outcome would be a powerful clinical tool. In this issue of the JCI, Malka et al. describe a dynamic system model of neutrophil bactericidal activity that confirms and extends the concept of critical neutrophil concentration. The authors demonstrate that when the neutrophil concentration approaches the critical concentration, bacterial populations in contact with them exhibit bistability. Their experimental findings raise the intriguing possibility of greater variability in bactericidal activity of neutrophils from healthy adults than heretofore recognized; their model predicts that this could have life-and-death consequences. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|