| Autor: |
Leong, Kelvin, Gautam, Sanjay S, Pradhan, Manoj, Singh, Y Ibotomba, Rajendra, KC, Rajbhandari, Sagar K, Ghimire, Gokarna R, Adhikari, Krishna, Shrestha, Uma, Chaudhary, Raina, Ghimire, Gyanendra, Khadka, Sundar, O'Toole, Ronan |
| Rok vydání: |
2022 |
| Předmět: |
|
| DOI: |
10.26181/19149551.v1 |
| Popis: |
Nepal exhibits a tuberculosis (TB) incidence rate that is comparable to neighbouring high TB incidence countries. In addition, it records >500 cases of multi-drug resistant (MDR) TB each year. The objective of this study was to perform whole-genome bioinformatic analysis on MDR-TB isolates from Nepal (n = 19) to identify the specific mutations underlying their phenotypic resistance. In addition, we examined the dominant genotype among the Nepal MDR-TB isolates, the East-Asian Beijing sub-lineage, to determine its relatedness to a panel of 1274 genomes of international strains available from public databases. These analyses provided evidence that the XDR-TB isolates in our collection were not derived from importation of primary XDR-TB to Nepal but were more likely the result of acquisition of second-line drug resistance in Nepal. Resistance to fluoroquinolones was detected among a high proportion of the Nepal isolates. This has implications for the management of TB, including appropriate antimicrobial stewardship and susceptibility testing for fluoroquinolones and other second-line TB drugs, to minimise the development of XDR-TB among Nepal TB cases. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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